Comparison of the antibacterial effect of silver sulfadiazine 1%, mupirocin 2%, Acticoat and octenidine dihydrochloride in a full-thickness rat burn model contaminated with multi drug resistant Acinetobacter baumannii

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dc.contributor.authorSelcuk, Caferi Tayyar
dc.contributor.authorDurgun, Mustafa
dc.contributor.authorOzalp, Burhan
dc.contributor.authorTekin, Alicem
dc.contributor.authorTekin, Recep
dc.contributor.authorAkcay, Cemal
dc.contributor.authorAlabalik, Ula
dc.date.accessioned2024-04-24T16:10:58Z
dc.date.available2024-04-24T16:10:58Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn this study, our aim is to compare the efficacy of different topical antibacterial agents in a rat model contaminated with a multi drug resistant (MDR) standard Acinetobacter baumannii strain. The study was carried out on 40 Sprague-Dawley rats of 250-300 g each. For the purposes of this study, the rats were divided into 5 groups, with 8 rats in each group: Group 1 control; Group 2 silver sulfadiazine; Group 3 mupirocin; Group 4 Acticoat group; and Group 5 octenidine dihydrochloride group. Following to the formation of the full-thickness burn areas in rats, the MDR A. baumannii standard strain was inoculated into the burned area. The rats in all the groups were sacrificed at the end of the 10th day and subjected to histopathological and microbiological evaluation. In the histopathological evaluation, the lowest inflammatory cell response and bacterial density in the eschar and muscle tissues were observed in the Acticoat group. While these results were found to be statistically significant compared to the silver sulfadiazine group, only the bacterial density in the muscle tissue was found as significant in comparison to the mupirocin and octenidine groups. In the microbiological evaluation, the lowest growth in the muscle tissue culture among all the groups was observed in the Acticoat group. The growth in the eschar tissue culture was significantly lower in the Acticoat and octenidine groups in comparison to the silver sulfadiazine group. At the end of the study, it has been observed that Acticoat was effective both in eschar and muscle, while octenidine was effective in eschar tissues in a rat burn model contaminated with MDR A. baumannii. (C) 2012 Elsevier Ltd and ISBI. All rights reserved.en_US
dc.identifier.doi10.1016/j.burns.2012.04.009
dc.identifier.endpage1209en_US
dc.identifier.issn0305-4179
dc.identifier.issue8en_US
dc.identifier.pmid22688192
dc.identifier.scopus2-s2.0-84868197457
dc.identifier.scopusqualityQ1
dc.identifier.startpage1204en_US
dc.identifier.urihttps://doi.org/10.1016/j.burns.2012.04.009
dc.identifier.urihttps://hdl.handle.net/11468/15211
dc.identifier.volume38en_US
dc.identifier.wosWOS:000311774300017
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofBurns
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBurnen_US
dc.subjectAcinetobacter Baumanniien_US
dc.subjectWound Healingen_US
dc.subjectOctenidine Dihydrochlorideen_US
dc.titleComparison of the antibacterial effect of silver sulfadiazine 1%, mupirocin 2%, Acticoat and octenidine dihydrochloride in a full-thickness rat burn model contaminated with multi drug resistant Acinetobacter baumanniien_US
dc.titleComparison of the antibacterial effect of silver sulfadiazine 1%, mupirocin 2%, Acticoat and octenidine dihydrochloride in a full-thickness rat burn model contaminated with multi drug resistant Acinetobacter baumannii
dc.typeArticleen_US

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