Effect of nitric oxide on phagocytic activity of lipopolysaccharide-induced macrophages

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dc.contributor.authorTumer, Cemil
dc.contributor.authorBilgin, Hakki Murat
dc.contributor.authorObay, Basra Deniz
dc.contributor.authorDiken, Huda
dc.contributor.authorAtmaca, Mukadder
dc.contributor.authorKelle, Mustafa
dc.date.accessioned2024-04-24T16:11:01Z
dc.date.available2024-04-24T16:11:01Z
dc.date.issued2007
dc.departmentDicle Üniversitesien_US
dc.description.abstractAmong the antimicrobial mechanisms associated with macrophages, NO produced by iNOS plays a major role in intracellular killing, but the relationship between NO and phagocytic activity after injection of inflammatory agents into the peritoneal cavity is not clear. The aim of the present study was to investigate the effect of nitric oxide (NO) on macrophage function after treatment with intraperitoneal lipopolysaccharide (LPS) and the role of exogenous L-arginine administration in this event. Six experimental groups and one control group, each consisting of seven Wistar rats were used: Group I: Control; Group II: LPS; Group III: LPS + L-arginine; Group IV: LPS + L-arginine + Aminoguanidine; Group V: LPS + Aminoguanidine; Group VI: L-arginine; Group VII: Aminoguanidine. Macrophage phagocytic activity and total plasma nitrite levels were increased in the LPS group. In the LPS + L-arginine group, both the phagocytic activity and total plasma nitrite levels showed large increases. Administration of aminoguanidine (AG), a specific iNOS inhibitor, abolished macrophage phagocytic activity and total plasma nitrite levels in the LPS and LPS + L-arginine groups. As a result, we showed that NO produced by macrophages has a role not only in intracellular killing, but also in phagocytic activity. (c) 2006 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.cellbi.2006.11.029
dc.identifier.endpage569en_US
dc.identifier.issn1065-6995
dc.identifier.issn1095-8355
dc.identifier.issue6en_US
dc.identifier.pmid17241792
dc.identifier.scopus2-s2.0-34247470765
dc.identifier.scopusqualityQ2
dc.identifier.startpage565en_US
dc.identifier.urihttps://doi.org/10.1016/j.cellbi.2006.11.029
dc.identifier.urihttps://hdl.handle.net/11468/15230
dc.identifier.volume31en_US
dc.identifier.wosWOS:000246663300005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofCell Biology International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNitric Oxideen_US
dc.subjectPhagocytic Activityen_US
dc.subjectL-Arginineen_US
dc.subjectAminoguanidineen_US
dc.subjectLipopolysaccharideen_US
dc.titleEffect of nitric oxide on phagocytic activity of lipopolysaccharide-induced macrophagesen_US
dc.titleEffect of nitric oxide on phagocytic activity of lipopolysaccharide-induced macrophages
dc.typeArticleen_US

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