Evaluation of adipocytokine levels and vascular functions in young aged to middle aged men with idiopathic hypogonadotrophic hypogonadism

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dc.contributor.authorTuna, Mazhar Muslum
dc.contributor.authorDogan, Berem Ayiek
dc.contributor.authorKarakilic, Ersen
dc.contributor.authorArduc, Ayse
dc.contributor.authorIsik, Serhat
dc.contributor.authorYilmaz, Fatma Meric
dc.contributor.authorTopcuoglu, Canan
dc.date.accessioned2024-04-24T17:33:50Z
dc.date.available2024-04-24T17:33:50Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: Hypogonadism has major effects on the urogenital system, in addition to other systems, the cardiovascular system in particular. There have been few studies conducted on markers of atherosclerosis, such as flow mediated dilatation (% FMD), carotid intima-media thickness (CIMT) and adipocytokine levels in idiopatic hypogonadotropic hypogonadal (IHH) males mostly in adult patients. The aim of this study was to evaluate the relationship between androgens and adipocytokines and parameters of vascular functions in hypogonadal men. MATERIALS AND METHODS: The study population consisted of 11 treatment naive IHH patients (group 1) and 15 age-matched healthy control males (group 2). A fasting blood sample was obtained for leptin, adiponectin and resistin. The endothelial functions were evaluated by studying % FMD and CIMT by high resolution B-mode ultrasound. RESULTS: No significant differences in age, body mass index, systolic and diastolic blood pressure were recorded between the two groups. The leptin level was significantly higher in group 1, whereas adiponectin and resistin levels were same between two groups. There was a negative correlation between total testosterone and carotid intima-media thickness (r=-0.656, p=0.008), and a negative correlation between total testosterone and leptin level (r=-0.794, p<0.001). No correlation was found between leptin and CIMT (p=0.184). CONCLUSION: Testosterone deficiency in hypogonadal men is associated with vascular parameters of atherosclerosis. The findings may establish indications for testosterone replacement therapy in hypogonadal men.en_US
dc.description.sponsorshipAnkara Numune Training and Research Hospitalen_US
dc.description.sponsorshipThis work was partially supported by grants from Ankara Numune Training and Research Hospital.en_US
dc.identifier.endpage644en_US
dc.identifier.issn0172-780X
dc.identifier.issue7en_US
dc.identifier.pmid25617889
dc.identifier.scopus2-s2.0-84924534650
dc.identifier.scopusqualityQ3
dc.identifier.startpage640en_US
dc.identifier.urihttps://hdl.handle.net/11468/20857
dc.identifier.volume35en_US
dc.identifier.wosWOS:000349384700013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherMaghira & Maas Publicationsen_US
dc.relation.ispartofNeuroendocrinology Letters
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdipocytokineen_US
dc.subjectVascular Functionsen_US
dc.subjectHypogonadotrophic Hypogonadismen_US
dc.titleEvaluation of adipocytokine levels and vascular functions in young aged to middle aged men with idiopathic hypogonadotrophic hypogonadismen_US
dc.titleEvaluation of adipocytokine levels and vascular functions in young aged to middle aged men with idiopathic hypogonadotrophic hypogonadism
dc.typeArticleen_US

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