Inhibition of Amyloid Aggregation Using Optimized Nano-Encapsulated Formulations of Plant Extracts with High Metal Chelator Activities

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dc.contributor.authorKazdal, Fatma
dc.contributor.authorBahadori, Fatemeh
dc.contributor.authorCelik, Burak
dc.contributor.authorErtas, Abdulselam
dc.contributor.authorTopcu, Gulacti
dc.date.accessioned2024-04-24T17:18:33Z
dc.date.available2024-04-24T17:18:33Z
dc.date.issued2020
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: The role of Fe+2, Cu+2 and Zn+2 in facilitating aggregation of Amyloid beta (A beta) and consequently, the progression of Alzheimer's disease (AD) is well established. Objective: Development of non-toxic metal chelators is an emerging era in the treatment of AD, in which complete success has not been fully achieved. The purpose of this study was to determine plant extracts with high metal chelator and to encapsulate them in nano-micellar systems with the ability to pass through the Blood Brain Barrier (BBB). Methods: Extracts of 36 different Anatolian plants were prepared, total phenolic and flavonoid contents were determined, and the extracts with high content were examined for their Fe+2, Cu+2 and Zn+2 chelating activities. Apolipoprotein E4 (Apo E) decorated nano-formulations of active extracts were prepared using Poly (Lactide-co-Glycolide) (PLGA) (final product ApoEPLGA) to provide BBB penetrating property. Results: Verbascum jlavidum aqueous extract was found as the most active sample, incubation of which, with A beta before and after metal-induced aggregation, resulted in successful inhibition of aggregate formation, while re-solubilization of pre-formed aggregates was not effectively achieved. The same results were obtained using ApoEPLGA. Conclusion: An optimized metal chelator nano-formulation with BBB penetrating ability was prepared and presented for further in vivo studies.en_US
dc.description.sponsorshipBezmialem Vakif University, Scientific Research and Development Support Program [9.2014/16]en_US
dc.description.sponsorshipThis study was funded by Bezmialem Vakif University, Scientific Research and Development Support Program, Grant No: 9.2014/16.en_US
dc.identifier.doi10.2174/1389201021666191210125851
dc.identifier.endpage701en_US
dc.identifier.issn1389-2010
dc.identifier.issn1873-4316
dc.identifier.issue8en_US
dc.identifier.pmid31820684
dc.identifier.scopus2-s2.0-85088200630
dc.identifier.scopusqualityQ2
dc.identifier.startpage681en_US
dc.identifier.urihttps://doi.org/10.2174/1389201021666191210125851
dc.identifier.urihttps://hdl.handle.net/11468/18827
dc.identifier.volume21en_US
dc.identifier.wosWOS:000548750600004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofCurrent Pharmaceutical Biotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlzheimeren_US
dc.subjectApo E4en_US
dc.subjectMetal Chelatoren_US
dc.subjectNano-Drug Deliveryen_US
dc.subjectPolyphenolen_US
dc.subjectAmyloid Betaen_US
dc.titleInhibition of Amyloid Aggregation Using Optimized Nano-Encapsulated Formulations of Plant Extracts with High Metal Chelator Activitiesen_US
dc.titleInhibition of Amyloid Aggregation Using Optimized Nano-Encapsulated Formulations of Plant Extracts with High Metal Chelator Activities
dc.typeArticleen_US

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