Elevated levels of tissue plasminogen activator and E-selectin in male children with autism spectrum disorder

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dc.contributor.authorŞimşek, Şeref
dc.contributor.authorÇetin, İhsan
dc.contributor.authorÇim, Abdullah
dc.contributor.authorKaya, Savaș
dc.contributor.orcid0000-0001-9568-5767
dc.date.accessioned2024-04-24T15:59:20Z
dc.date.available2024-04-24T15:59:20Z
dc.date.issued2016
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk ve Ergen Ruh Sağlığı Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractAlthough the etiopathology of autism spectrum disorder (ASD) is not clear, immune dysfunction has been proposed as a mechanism for the pathophysiology of ASD. The purpose of this study is to examine serum levels of tissue plasminogen activator (t-PA) and some adhesion molecules in children with ASD that have not been investigated previously in detail. The study group included 35 male children aged from 2 to 9 diagnosed with ASD according to DSM-V criteria. Soluble platelet endothelial adhesion molecule-1 (sPECAM-1), P-selectin, E-selectin, and t-PA in the serum were determined with enzyme-linked immunosorbent assay. Autism behavior check list (ABC) is used for the assessment of ASD severity. The levels of t-PA (P=0.025) and E-selectin (P=0.007) was detected significantly higher in children with ASD than control group. Serum levels of sPECAM-1 showed statistically significant negative correlation with sensory, body and object-use, language, social, and self-help and total scores in the patient group (r=-0.349, P=0.04; r=-0.411, P=0.01; r=-0.412, P=0.01; r=-0.417, P=0.01, and r=-0.531, P<0.01, respectively). Serum levels of P-selectin levels showed statistically significant negative correlation with ABC total score in the patient group (r=-0.378, P=0.03). It may be suggested that t-PA, E-selectin, P-selectin, and sPECAM-1 a crucial role in inflammatory conditions in children with ASD. Autism Res2016, 9: 1241-1247. (c) 2016 International Society for Autism Research, Wiley Periodicals, Inc.en_US
dc.identifier.citationŞimşek, Ş., Çetin, İ., Çim, A. ve Kaya, S. (2016). Elevated levels of tissue plasminogen activator and E-selectin in male children with autism spectrum disorder. Autism Research, 9(12), 1241-1247.
dc.identifier.doi10.1002/aur.1638
dc.identifier.endpage1247en_US
dc.identifier.issn1939-3792
dc.identifier.issn1939-3806
dc.identifier.issue12en_US
dc.identifier.pmid27194368
dc.identifier.scopus2-s2.0-85006970322
dc.identifier.scopusqualityQ1
dc.identifier.startpage1241en_US
dc.identifier.urihttps://doi.org/10.1002/aur.1638
dc.identifier.urihttps://hdl.handle.net/11468/13984
dc.identifier.volume9en_US
dc.identifier.wosWOS:000393686700002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorŞimşek, Şeref
dc.institutionauthorÇim, Abdullah
dc.institutionauthorKaya, Savaș
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofAutism Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutism spectrum disorderen_US
dc.subjectInflammationen_US
dc.subjectSelectinen_US
dc.subjectTissue pasminogen activatoren_US
dc.subjectSpecam-1en_US
dc.titleElevated levels of tissue plasminogen activator and E-selectin in male children with autism spectrum disorderen_US
dc.titleElevated levels of tissue plasminogen activator and E-selectin in male children with autism spectrum disorder
dc.typeArticleen_US

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