Lc-ms/ms simultaneous determination of 37 bioactive compounds in bunium crassifolium batt. And its biological activities

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dc.authorid0000-0001-7762-9657en_US
dc.authorid0000-0002-2089-8618en_US
dc.authorid0000-0003-1704-5515en_US
dc.authorid0000-0001-7383-5453en_US
dc.authorid0000-0001-8932-4535en_US
dc.authorid0000-0002-2193-8386en_US
dc.contributor.authorSouilah, Nabila
dc.contributor.authorBendif, Hamdi
dc.contributor.authorUllah, Zain
dc.contributor.authorHamel, Tarek
dc.contributor.authorDjarri, Lakhdar
dc.contributor.authorÖztürk, Mehmet
dc.contributor.authorErtaş, Abdulselam
dc.date.accessioned2024-01-02T13:28:59Z
dc.date.available2024-01-02T13:28:59Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractBunium crassifolium Batt. is an extremely rare species growing in Algeria. Its leaf or aerial part is used for flavoring and garnishing food. The aim of the current study was to determine 37 bioactive phytochemicals and biological evaluation of the methanol and methanol:water (70:30) extracts of B. crassifolium for the first time. A total of 10 phenolic acids and 8 flavonoids have been identified in the extracts of the aerial parts by LC–MS/MS. Chlorogenic, gallic and ferulic acids were the most abundant phenolic acids detected, while rhoifolin, quercitrin and rutin were the most abundant flavonoids. In addition, 3 non-phenolic organic acids (fumaric acids, quinic and malic) were detected and among them quinic and malic acids were the most abundant. Antioxidant activity was evaluted by six methods and the extracts showed significant activity. The total phenolic and flavonoid contents were determined and methanol:water (70:30) extract showed higher values which entails its greater antioxidant capacity. In addition, anticholinesterase (AChE and BChE) activity was evaluated for both extracts using Ellman method. Methanol extract showed a better anti-acetylcholinesterase activity than methanol:water (70:30) one. While, both extracts showed a weak anti-butyrylcholinesterase activity. Furthermore, the anti-tyrosinase activity was tested and the methanol:water (70:30) extract was promising and more potent. In conclusion, B. crassifolium could be used in food industries and pharmaceutical as a potential functional food ingredient.en_US
dc.identifier.citationSouilah, N., Bendif, H., Ullah, Z., Hamel, T., Djarri, L., Öztürk, M. ve diğerleri. (2021). Lc-ms/ms simultaneous determination of 37 bioactive compounds in bunium crassifolium batt. And its biological activities. Journal of Research in Pharmacy, 25(4), 450-463.en_US
dc.identifier.doi10.29228/jrp.36
dc.identifier.endpage463en_US
dc.identifier.issn2630-6344
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85111564706
dc.identifier.scopusqualityQ3
dc.identifier.startpage450en_US
dc.identifier.trdizinid459865
dc.identifier.urihttps://jrespharm.com/abstract.php?id=906
dc.identifier.urihttps://hdl.handle.net/11468/13129
dc.identifier.volume25en_US
dc.identifier.wosWOS:000678159500011
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorErtaş, Abdulselam
dc.language.isoenen_US
dc.publisherMarmara Universityen_US
dc.relation.ispartofJournal of Research in Pharmacy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnticholinesterase activityen_US
dc.subjectAntioxidant activityen_US
dc.subjectBunium crassifoliumen_US
dc.subjectLC-MS/MSen_US
dc.subjectTyrosinase inhibitionen_US
dc.titleLc-ms/ms simultaneous determination of 37 bioactive compounds in bunium crassifolium batt. And its biological activitiesen_US
dc.titleLc-ms/ms simultaneous determination of 37 bioactive compounds in bunium crassifolium batt. And its biological activities
dc.typeArticleen_US

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