A novel nutritional supplement containing chromium picolinate, phosphatidylserine, docosahexaenoic acid, and boron activates the antioxidant pathway Nrf2/HO-1 and protects the brain against oxidative stress in high-fat-fed rats

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dc.contributor.authorSahin, Nurhan
dc.contributor.authorAkdemir, Fatih
dc.contributor.authorOrhan, Cemal
dc.contributor.authorAslan, Abdullah
dc.contributor.authorAgca, Can A.
dc.contributor.authorGencoglu, Hasan
dc.contributor.authorUlas, Mustafa
dc.date.accessioned2024-04-24T17:14:47Z
dc.date.available2024-04-24T17:14:47Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractAims: A novel nutritional supplement complex (N21 #125) composed of four well-known compounds (chromium picolinate, phosphatidylserine, docosahexaenoic acid, and boron) was designed to improve memory function and maintain brain health. The present study evaluated the complex's potential mechanism of action and its role in reducing oxidative stress in the brain of obese rats fed a high-fat diet (HFD). Methods: Male Wistar rats (n = 40, 8-week-old) were divided into four groups. Group I was fed a standard diet; Group II was fed a standard diet and supplemented with N21 #125; Group III was fed an HFD; and Group IV was fed an HFD and supplemented with N21 #125 for 12 weeks. Results: Rats fed HFD had greater serum C-reactive protein (CRP) and tumor necrosis factor alpha (TNF-alpha) and brain malondialdehyde (MDA) concentrations than rats fed the control diet. Supplementation of N21 #125 decreased CRP, TNF-a, and MDA concentration in rats fed HFD. The levels of brain nuclear factor-E2-related factor-2 (Nrf2), heme oxygenase, extracellular signal-regulated kinases and protein kinase B were lower in rats fed the control diet than for rats fed the HFD. These parameters were increased by supplementation of N21 #125. Discussion: The data indicate that N21 #125 protected the brain from oxidative damage and inflammation induced by the HFD. This effect may be through up-regulation of the transcription factor Nrf2 expression.en_US
dc.description.sponsorshipNutrition 21, Inc., NY, USAen_US
dc.description.sponsorshipThe study was funded by Nutrition 21, Inc., NY, USA. Nutrition 21 also supplied the Chromax (R) chromium picolinate, phosphatidylserine, docosahexaenoic acid, and boron used in the study. James Komorowski is an employee of Nutrition 21, the distributors of Chromax (R) chromium picolinate.en_US
dc.identifier.doi10.1179/1476830512Y.0000000018
dc.identifier.endpage47en_US
dc.identifier.issn1028-415X
dc.identifier.issn1476-8305
dc.identifier.issue5en_US
dc.identifier.pmid23232054
dc.identifier.scopus2-s2.0-84867059969
dc.identifier.scopusqualityQ1
dc.identifier.startpage42en_US
dc.identifier.urihttps://doi.org/10.1179/1476830512Y.0000000018
dc.identifier.urihttps://hdl.handle.net/11468/18191
dc.identifier.volume15en_US
dc.identifier.wosWOS:000309519400006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofNutritional Neuroscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHigh-Fat Dieten_US
dc.subjectNrf2/Ho-1en_US
dc.subjectOxidative Stressen_US
dc.titleA novel nutritional supplement containing chromium picolinate, phosphatidylserine, docosahexaenoic acid, and boron activates the antioxidant pathway Nrf2/HO-1 and protects the brain against oxidative stress in high-fat-fed ratsen_US
dc.titleA novel nutritional supplement containing chromium picolinate, phosphatidylserine, docosahexaenoic acid, and boron activates the antioxidant pathway Nrf2/HO-1 and protects the brain against oxidative stress in high-fat-fed rats
dc.typeArticleen_US

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