Changes in serum levels of leptin, cytokines and lipoprotein in preeclamptic and normotensive pregnant women

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dc.contributor.authorKoçyigit, Y
dc.contributor.authorAtamer, Y
dc.contributor.authorAtamer, A
dc.contributor.authorTuzcu, A
dc.contributor.authorAkkus, Z
dc.date.accessioned2024-04-24T16:24:43Z
dc.date.available2024-04-24T16:24:43Z
dc.date.issued2004
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the changes in serum levels of leptin, cytokines and lipoproteins in women with pre-eclampsia and to evaluate their clinical significance in the pathogenesis of pre-eclampsia. We performed a prospective study involving 45 women with pre-eclampsia in the third trimester of pregnancy and 30 normotensive women in the third trimester of pregnancy. Serum level of leptin was measured by enzyme immunoassay using a Cayman chemical kit, Serum levels of tumor necrosis factor (TNF)-alpha, intertleukin (IL)-1beta, soluble IL-2 receptor (sIL-2R), IL-6 and IL-8 were measured by using a nonradioimmunoassay chemiluminescent method. Serum lipid concentrations were measured by an Abbott Aeroset (USA) autoanalyzer. Serum levels of apolipoprotein (Apo)A-I and ApoB were evaluated by nephelometrics assays. Differences between groups were evaluated with Student's unpaired t test and, when a variable was not normally distributed, the Mann-Whitney U test was used. The relationship between the variable was explored by the Pearson correlation test. Serum levels of leptin, TNF-alpha, IL-1beta, sIL-2R, IL-6 and IL-8 in the preeclamptic women were significantly higher than in normotensive women (p < 0.001). In the pre-eclamptic women serum levels of triglycerides, total cholesterol and low-density lipoprotein (LDL)-cholesterol were significantly increased (p < 0.001), while high-density lipoprotein (HDL)-cholesterol and Apo-A were significantly decreased compared to levels in normotensive pregnant women (p < 0.001). No significant differences were noted between the groups in Apo-? (p > 0.05). Serum levels of TNF-? were significantly correlated with the serum levels of IL-6, IL-8, triglycerides, sIL-2R, Apo-A and hematocrit in pre-eclamptic women (r = 0.418, p < 0.05 - r = 0.389, p < 0.01; r = 0.312, p < 0.05; r 0.318, p < 0.05; r 0.340, p < 0.05 and r = 0.41, p < 0,01, respectively). A negative correlation was seen between serum level of leptin and both IL-1? and Apo-A in pre-eclamptic women (r = 0.44, p < 0.05; r = 0.39, p < 0.05, respectively). Serum levels of IL-6 were also signficantly correlated with the serum levels of HDL-cholesterol, LDL-cholesterol and body mass index (BMI) in preeclamptic women (r = 0.40, p < 0.01; r = 0.568, p < 0. 0 1; r 0. 3 0, p < 0. 05, respectively). In addition, serum level of IL-8 were significantly correlated with the serum levels of HDL-cholesterol, total cholesterol and BMI in pre-eclamptic women (r = 0.368, p < 0.05; r = 0.513, p < 0.01 and r = 0.41, p < 0.01, respectively). We found that the pre-eclampsia associated with increases in serum levels of leptin, TNF-?, cytokines, triglycerides, total cholesterol and LDL-cholesterol was associated with a significant reduction in serum levels of HDL-cholesterol and Apo-A. These association may be due to the abnormal lipid metabolism and immune activation involved in the pathogenesis of this disease.en_US
dc.identifier.doi10.1080/09513590400018108
dc.identifier.endpage273en_US
dc.identifier.issn0951-3590
dc.identifier.issue5en_US
dc.identifier.pmid15726915
dc.identifier.scopus2-s2.0-12344276643
dc.identifier.scopusqualityQ2
dc.identifier.startpage267en_US
dc.identifier.urihttps://doi.org/10.1080/09513590400018108
dc.identifier.urihttps://hdl.handle.net/11468/16829
dc.identifier.volume19en_US
dc.identifier.wosWOS:000226569700006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherParthenon Publishing Groupen_US
dc.relation.ispartofGynecological Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPre-Eclampsiaen_US
dc.subjectTumour Necposis Factor-Alphaen_US
dc.subjectLeptinen_US
dc.subjectCytokinesen_US
dc.subjectLipoproteinsen_US
dc.titleChanges in serum levels of leptin, cytokines and lipoprotein in preeclamptic and normotensive pregnant womenen_US
dc.titleChanges in serum levels of leptin, cytokines and lipoprotein in preeclamptic and normotensive pregnant women
dc.typeArticleen_US

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