Protective effects of coumarin and coumarin derivatives against carbon tetrachloride-induced acute hepatotoxicity in rats

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dc.contributor.authorBilgin, Hakki Murat
dc.contributor.authorAtmaca, Mukadder
dc.contributor.authorObay, Basra Deniz
dc.contributor.authorOzekinci, Selver
dc.contributor.authorTasdemir, Ezel
dc.contributor.authorKetani, Aydin
dc.date.accessioned2024-04-24T16:11:27Z
dc.date.available2024-04-24T16:11:27Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe comparison of the antioxidant activity of some coumarins with their molecular structure is well determined. However, the protective function of coumarins with various chemical structures against liver toxicity has not yet been well established. Therefore, the aim of this study was to evaluate the possible cytoprotective properties of coumarin and some coumarin derivatives against CCl(4) (carbon tetrachloride)-induced hepatotoxicity. Coumarin (1,2-benzopyrone) and coumarin derivatives esculetin (6,7-dihydroxycoumarin), scoparone (6,7-dimethoxycoumarin) and 4-methylumbelliferone (7-hyroxy-4-methyl) were examined for their protective effect against CCl(4)-induced hepatotoxicity in Male Sprague-Dawley rats. A single toxic dose of CCl(4) (1.25 ml kg(-1), orally) produced liver damage in rats, seen histologically as centrilobular necrosis. Administration of CCl(4) increased serum enzyme levels of aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP). Pretreatment of rats with esculetin (31.15 mg kg(-1), orally) and scoparone (35 mg kg(-1), orally) significantly prevented CCl(4)-induced increase in serum enzymes, whereas 4-methylumbelliferone (35 mg kg(-1)) and coumarin (30 mg kg(-1)) had no effect against CCl(4)-induced rise in serum enzymes. Morphological findings were consistent with the plasma transaminase observations. Among the coumarin analogs, esculetin, which possesses orthodihydroxy coumarins, showed the strongest protective effect against CCl(4)-induced liver damage, followed by scoparone, 4-methylumbelliferone and coumarin, respectively. The results of this study indicate that the chemical structures of coumarins play an important role in the prevention of liver toxicity. (C) 2010 Elsevier GmbH. All rights reserved.en_US
dc.description.sponsorshipDicle University [DUAPK 03-TF-42]en_US
dc.description.sponsorshipFinancial support for this study was provided by Dicle University, administered through the Research Project Unit (Project no.: DUAPK 03-TF-42).en_US
dc.identifier.doi10.1016/j.etp.2010.02.006
dc.identifier.endpage330en_US
dc.identifier.issn0940-2993
dc.identifier.issue4en_US
dc.identifier.pmid20207117
dc.identifier.scopus2-s2.0-79953753446
dc.identifier.scopusqualityN/A
dc.identifier.startpage325en_US
dc.identifier.urihttps://doi.org/10.1016/j.etp.2010.02.006
dc.identifier.urihttps://hdl.handle.net/11468/15396
dc.identifier.volume63en_US
dc.identifier.wosWOS:000290738900005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Gmbh, Urban & Fischer Verlagen_US
dc.relation.ispartofExperimental and Toxicologic Pathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoumarinsen_US
dc.subjectHepatotoxicityen_US
dc.subjectCcl(4)en_US
dc.subjectRatsen_US
dc.titleProtective effects of coumarin and coumarin derivatives against carbon tetrachloride-induced acute hepatotoxicity in ratsen_US
dc.titleProtective effects of coumarin and coumarin derivatives against carbon tetrachloride-induced acute hepatotoxicity in rats
dc.typeArticleen_US

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