The effects of caffeic acid phenethyl ester on retina in a diabetic rat model

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dc.contributor.authorSahin, Alparslan
dc.contributor.authorKaya, Savas
dc.contributor.authorBaylan, Mukadder
dc.date.accessioned2024-04-24T17:07:52Z
dc.date.available2024-04-24T17:07:52Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose We aimed to investigate the effect of caffeic acid phenethyl ester (CAPE) on retinal apoptosis and oxidative stress parameters in streptozotocin (STZ) induced diabetic rat model. Methods This study included 3 groups; control, STZ, and STZ + CAPE. The rats in STZ, and STZ + CAPE groups were injected with STZ (35 mg/kg, i.p.) for induction of diabetes. In the STZ + CAPE group, 10 mu mol/kg of CAPE were intraperitoneally injected for 4 weeks. Control and STZ groups were given only intraperitoneal vehicle (saline). Rats were anaesthetized and sacrificed on the 4th week of the experiment. Total anti-oxidant status (TAS), and total oxidant status (TOS) were measured on the dissected retinal tissues. Oxidative stress index (OSI) was also calculated. Fellow eyes were used for histopathologic evaluation with caspase-3 and matrix metalloproteinase-2 (MMP-2) and MMP-9 evaluation. Results TAS levels were similar between groups (p = 0.71). However, CAPE treatment prevented the elevation of the TOS in the STZ + CAPE group compared to the STZ group (30.93 +/- 9.97 vs 61.53 +/- 24.7 nmol H2O2 Eq/mg protein, p = 0.007). OSI was also significantly lower in the STZ + CAPE group than that of the STZ group (20.01 +/- 5.87 vs. 37.90 +/- 14.32, respectively, p = 0.007). Retinal caspase-3 staining, MMP-2 and MMP-9 scores were not different between groups (p > 0.05 for all). Conclusion The present study demonstrated that CAPE treatment may decrease the oxidative stress in the retina in STZ induced diabetic rat model. However, apoptosis was not observed in the retina. The retinal apoptosis cannot be shown probably due to a shorter period of diabetes.en_US
dc.identifier.doi10.1080/15569527.2021.1940196
dc.identifier.endpage273en_US
dc.identifier.issn1556-9527
dc.identifier.issn1556-9535
dc.identifier.issue3en_US
dc.identifier.pmid34165369
dc.identifier.scopus2-s2.0-85108446778
dc.identifier.scopusqualityQ3
dc.identifier.startpage268en_US
dc.identifier.urihttps://doi.org/10.1080/15569527.2021.1940196
dc.identifier.urihttps://hdl.handle.net/11468/17053
dc.identifier.volume40en_US
dc.identifier.wosWOS:000665714600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofCutaneous and Ocular Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti-Oxidant Capacityen_US
dc.subjectCaffeic Acid Phenethyl Esteren_US
dc.subjectCaspase-3en_US
dc.subjectDiabetes Mellitusen_US
dc.subjectDiabetic Retinopathyen_US
dc.subjectOxidative Stressen_US
dc.subjectStreptozotocinen_US
dc.titleThe effects of caffeic acid phenethyl ester on retina in a diabetic rat modelen_US
dc.titleThe effects of caffeic acid phenethyl ester on retina in a diabetic rat model
dc.typeArticleen_US

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