Amniotic fluid paraoxonase-1 activity, thyroid hormone concentration and oxidant status in neural tube defects

Basit Öğe Kaydı
dc.contributor.authorSak, Sibel
dc.contributor.authorAgacayak, Elif
dc.contributor.authorTunc, Senem Yaman
dc.contributor.authorIcen, Mehmet Sait
dc.contributor.authorFindik, Fatih Mehmet
dc.contributor.authorSak, Muhammet Erdal
dc.contributor.authorYalinkaya, Ahmet
dc.date.accessioned2024-04-24T17:11:44Z
dc.date.available2024-04-24T17:11:44Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractAimThe aim of this study was to investigate the potential association between neural tube defects and paraoxonase-1 activity in amniotic fluid. We studied total oxidant status, total antioxidant capacity, paraoxonase-1 activity and thyroid hormone amniotic fluid concentration in fetuses with neural tube defects. MethodsThe present study was performed at the Department of Obstetrics and Gynaecology and the Department of Clinical Biochemistry of Dicle University between September 2011 and June 2013. The study group included 37 amniotic fluid samples from pregnant women (16-20 weeks of gestation) with fetuses affected by neural tube defects. The control group consisted of 36 pregnant women who were diagnosed with a high-risk pregnancy according to first or second trimester aneuploidy screening and were later confirmed on amniocentesis to have genetically normal fetuses. ResultsAmniotic fluid paraoxonase-1 activity and total oxidant status were significantly higher (P = 0.023, P = 0.029, respectively) whereas free T4 was significantly lower (P = 0.022) in fetuses with neural tube defects compared with control subjects. In fetuses with neural tube defects, amniotic fluid paraoxonase-1 activity correlated positively with total oxidant status (r = 0.424**, P = 0.010), and amniotic fluid total antioxidant capacity correlated positively with free t4 (r = 0.381*, P=0.022). ConclusionThis is the first study in the literature to show an association between paraoxonase-1 activity and thyroid hormone concentration and neural tube defects.en_US
dc.identifier.doi10.1111/jog.13026
dc.identifier.endpage1085en_US
dc.identifier.issn1341-8076
dc.identifier.issn1447-0756
dc.identifier.issue9en_US
dc.identifier.pmid27325571
dc.identifier.scopus2-s2.0-84985937237
dc.identifier.scopusqualityQ2
dc.identifier.startpage1080en_US
dc.identifier.urihttps://doi.org/10.1111/jog.13026
dc.identifier.urihttps://hdl.handle.net/11468/17701
dc.identifier.volume42en_US
dc.identifier.wosWOS:000383629300002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofJournal of Obstetrics and Gynaecology Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFree T4en_US
dc.subjectNeural Tube Defecten_US
dc.subjectOxidant Statusen_US
dc.subjectParaoxonase-1 Activityen_US
dc.titleAmniotic fluid paraoxonase-1 activity, thyroid hormone concentration and oxidant status in neural tube defectsen_US
dc.titleAmniotic fluid paraoxonase-1 activity, thyroid hormone concentration and oxidant status in neural tube defects
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu