Platelet-to-lymphocyte ratio is a predictor of in-hospital mortality patients with acute coronary syndrome

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dc.contributor.authorOylumlu, Mustafa
dc.contributor.authorYildiz, Abdulkadir
dc.contributor.authorOylumlu, Muhammed
dc.contributor.authorYuksel, Murat
dc.contributor.authorPolat, Nihat
dc.contributor.authorBilik, Mehmet Zihni
dc.contributor.authorAkyuz, Abdurrahman
dc.date.accessioned2024-04-24T17:25:03Z
dc.date.available2024-04-24T17:25:03Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Platelets and inflammatory cells are vital elements of acute coronary syndromes (ACS). Recent studies have shown that the platelet-to-lymphocyte ratio (PLR) is associated with several malignancies; however, there are not enough data in cardiovascular diseases. Therefore, the aim of this study was to explore the association between PLR and in-hospital mortality in patients with ACS. Methods: We retrospectively collected patients with ACS undergoing coronary angiography. Total and differential leukocyte counts were measured by an automated hematology analyzer. Results: This study is single-centered and observational. In total, 587 patients with a mean age of 61.8 +/- 13.1 years (68.4% male) were enrolled in the study. Patients were divided into 3 tertiles based on PLR levels. In-hospital mortality was significantly higher among patients in the upper PLR tertile when compared with the middle and lower PLR tertile groups [29 (14.8%) vs. 17 (8.7%) and 2 (1.0%); p<0.001]. In the multiple logistic regression analysis, a high level of PLR was an independent predictor of in-hospital mortality, together with age, total leukocyte count, and creatinine. Using a cutoff point of 142, the PLR predicted in-hospital mortality with a sensitivity of 69% and specificity of 63%. Conclusion: Different from other inflammatory markers and assays, PLR is an inexpensive and readily available biomarker that may be useful for cardiac risk stratification in patients with ACS.en_US
dc.identifier.doi10.5152/akd.2014.5366
dc.identifier.endpage283en_US
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue4en_US
dc.identifier.pmid25413224
dc.identifier.startpage277en_US
dc.identifier.trdizinid170641
dc.identifier.urihttps://doi.org/10.5152/akd.2014.5366
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/170641
dc.identifier.urihttps://hdl.handle.net/11468/19919
dc.identifier.volume15en_US
dc.identifier.wosWOS:000355106500002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTurkish Soc Cardiologyen_US
dc.relation.ispartofAnatolian Journal of Cardiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute Coronary Syndromeen_US
dc.subjectCoronary Heart Diseaseen_US
dc.subjectMortalityen_US
dc.subjectPlatelet-To-Lymphocyte Ratioen_US
dc.titlePlatelet-to-lymphocyte ratio is a predictor of in-hospital mortality patients with acute coronary syndromeen_US
dc.titlePlatelet-to-lymphocyte ratio is a predictor of in-hospital mortality patients with acute coronary syndrome
dc.typeArticleen_US

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