Investigation of algerian crataegus monogyna jacq phenolic compounds (Using LC-ESI-MS/MS analysis, antioxidant activity, and enzyme inhibition) and their potential implications for food and nutraceutical applications

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dc.authorid0000-0002-1946-736Xen_US
dc.authorid0000-0001-9797-1097en_US
dc.authorid0009-0001-6401-5389en_US
dc.authorid0000-0002-4090-7227en_US
dc.authorid0000-0002-7479-8970en_US
dc.authorid0000-0003-4467-5387en_US
dc.authorid0000-0002-8006-2054en_US
dc.contributor.authorGoudjil, Sabrina
dc.contributor.authorBoussekine, Samira
dc.contributor.authorGoudjil, Sarra
dc.contributor.authorGoudjil, Hanane
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.contributor.authorOla, Mohammad Shamsul
dc.contributor.authorAli, Ahmad
dc.contributor.authorÇakır, Oğuz
dc.date.accessioned2025-02-20T12:07:01Z
dc.date.available2025-02-20T12:07:01Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractInvestigations into the phenolic constituents of the butanolic fraction of Crataegus monogyna were optimized using LC-ESI-MS/MS analysis, identifying and quantifying at least 23 fingerprint phytochemical compounds. The major phenolic compounds were epicatechin (99.916 ± 2.208 mg/g), isoquercetrin (53.31 ± 1.172 mg/g), chlorogenic acid (47.457 ± 1.010 mg/g), quinic acid (37.819 ± 1.406 mg/g), rutin (29.98 ± 0.740 mg/g), hesperidin (5.296 ± 0.177 mg/g, detected for the first time in the C. monogyna species), astragalin (1.774 ± 0.020 mg/g), and nicotiflorin (1.482 ± 0.016 mg/g). The antioxidant properties of the lyophilized butanolic fraction were evaluated using DPPH, GOR, ABTS, CUPRAC, and reducing power assays, all of which demonstrated that there was strong activity. Additionally, the neuroprotective effect was evaluated in vitro, showing a potent inhibitory effect on acetylcholinesterase (AChE) with an IC50 of 43.65 ± 2.10 µg/mL. The antidiabetic effect was investigated through α-amylase inhibition (IC50 = 91.19 ± 0.10 µg/mL), showing high inhibitory activity. In addition, the butanolic extract exhibited significant urease inhibition with an IC50 of 26.36 ± 0.05 µg/mL. These results suggest that Algerian C. monogyna has potential as a therapeutic agent for managing diabetes complications and as a natural source of AChE inhibitors, making it a promising subject for the treatment of urease-related conditions. Its high concentrations of natural antioxidants, such as epicatechin, isoquercetrin, chlorogenic acid, quinic acid, rutin, hesperidin, and astragalin, make it suitable for integration into medicine, pharmaceuticals, cosmetics, and the food sector.en_US
dc.identifier.citationGoudjil, S., Boussekine, S., Goudjil, S., Goudjil, H., Yılmaz, M. A., Ola, M. S. ve diğerleri. (2024). Investigation of algerian crataegus monogyna jacq phenolic compounds (Using LC-ESI-MS/MS analysis, antioxidant activity, and enzyme inhibition) and their potential implications for food and nutraceutical applications. Antioxidants, 13(11), 1-25.en_US
dc.identifier.endpage25en_US
dc.identifier.issn2076-3921
dc.identifier.issue11en_US
dc.identifier.pmid39594492
dc.identifier.scopus2-s2.0-85210230844
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.mdpi.com/2076-3921/13/11/1350
dc.identifier.urihttps://hdl.handle.net/11468/29478
dc.identifier.volume13en_US
dc.identifier.wosWOS:001363642000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorYılmaz, Mustafa Abdullah
dc.institutionauthorÇakır, Oğuz
dc.language.isoenen_US
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)en_US
dc.relation.ispartofAntioxidants
dc.relation.isversionof10.3390/antiox13111350en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidant activityen_US
dc.subjectButanolic fractionen_US
dc.subjectCrataegus monogyna Jacqen_US
dc.subjectHesperidinen_US
dc.subjectLC-ESI-MS/MSen_US
dc.subjectPolyphenolen_US
dc.subjectUreaseen_US
dc.subjectα-amylaseen_US
dc.subjectAChEen_US
dc.titleInvestigation of algerian crataegus monogyna jacq phenolic compounds (Using LC-ESI-MS/MS analysis, antioxidant activity, and enzyme inhibition) and their potential implications for food and nutraceutical applicationsen_US
dc.titleInvestigation of algerian crataegus monogyna jacq phenolic compounds (Using LC-ESI-MS/MS analysis, antioxidant activity, and enzyme inhibition) and their potential implications for food and nutraceutical applications
dc.typeArticleen_US

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