Exogenous human recombinant interleukin-10 protects the kidney against hypoxia-induced renal injury in immature rats

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dc.contributor.authorOzturk, Hayrettin
dc.contributor.authorOnen, Abdurrahman
dc.contributor.authorOzturk, Hulya
dc.contributor.authorBuyukbayram, Huseyin
dc.date.accessioned2024-04-24T17:11:34Z
dc.date.available2024-04-24T17:11:34Z
dc.date.issued2006
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: The purpose of this study was to determine the effects of exogenous human recombinant interleukin-10 (rhIL-10) on hypoxia-induced renal injury in immature rats. Method: The study was performed on 1-day-old Sprague-Dawley rat pups. Group 1 (n = 8) served as non-hypoxic controls. Group 2 (untreated, n = 8) rats were subjected to hypoxia-reoxygenation (H/O) and were then returned to their mothers. Group 3 (rhIL-10 treated, n = 8) rats were subjected to H/O, were returned to their mothers, and were treated with rhIL-10 (75 mu g/kg subcutaneously) for the next 3 days. All animals were killed on day 4 and renal specimens were obtained to determine the tissue level of malondialdehyde (MDA) and histological changes. Results: In the untreated group, moderate or severe renal tubular necrosis was observed However, the tubular necrosis score was significantly less in the rhIL-10 treated rats than in the untreated rats (P < 0.05). In the untreated group, MDA levels were significantly increased compared with the control and rhIL-10 groups (P < 0.001 and P < 0.05, respectively). In the rhIL-10 treated group, MDA levels were not significantly different compared with the control group. Conclusion: RhIL-10 has a protective effect against hypoxia-induced renal injury in immature rats by depression of tissue MDA level and renal tubular necrosis score.en_US
dc.identifier.doi10.1111/j.1442-2042.2006.01304.x
dc.identifier.endpage400en_US
dc.identifier.issn0919-8172
dc.identifier.issue4en_US
dc.identifier.pmid16734858
dc.identifier.scopus2-s2.0-33744823046
dc.identifier.scopusqualityQ1
dc.identifier.startpage397en_US
dc.identifier.urihttps://doi.org/10.1111/j.1442-2042.2006.01304.x
dc.identifier.urihttps://hdl.handle.net/11468/17602
dc.identifier.volume13en_US
dc.identifier.wosWOS:000237739800014
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofInternational Journal of Urology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCytokineen_US
dc.subjectInjuryen_US
dc.subjectInterleukin-10en_US
dc.subjectRenal Ischemiaen_US
dc.titleExogenous human recombinant interleukin-10 protects the kidney against hypoxia-induced renal injury in immature ratsen_US
dc.titleExogenous human recombinant interleukin-10 protects the kidney against hypoxia-induced renal injury in immature rats
dc.typeArticleen_US

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