Investigation of the prognostic value of adipokines in multiple sclerosis

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dc.contributor.authorCoban, Arzu
dc.contributor.authorDuzel, Berna
dc.contributor.authorTuzun, Erdem
dc.contributor.authorTamam, Yusuf
dc.date.accessioned2024-04-24T16:15:39Z
dc.date.available2024-04-24T16:15:39Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Adipokines may be involved in multiple sclerosis (MS) as well as other inflammatory diseases. This study aimed to analyze the value of serum adipokine levels as biomarkers in determining the clinical progression of MS. Methods: A total of 90 subjects including 40 healthy individuals and 50 MS patients [24 with classical clinical course of MS (C-MS), 26 with benign MS (B-MS)] were recruited for this study. The levels of serum adipokines and inflammatory mediators were measured using immunoassay methods. Results: The levels of adiponectin, MCP-1, TNF-alpha and IL-6 were significantly higher in C-MS patients compared with B-MS patients and healthy controls. Only adiponectin and MCP-1 levels remained significantly high after Bonferroni correction. Adiponectin, MCP-1 and TNF-alpha levels showed a modest correlation with expanded disability status scale (EDSS) scores, which disappeared after Bonferroni correction. Conclusions: Our findings suggest the potential role of adipokines in pathogenesis and clinical progression of MS. Adiponectin and MCP-1 might potentially serve as prognostic biomarkers in MS.en_US
dc.identifier.doi10.1016/j.msard.2017.04.006
dc.identifier.endpage14en_US
dc.identifier.issn2211-0348
dc.identifier.issn2211-0356
dc.identifier.pmid28641765
dc.identifier.scopus2-s2.0-85018648116
dc.identifier.scopusqualityQ2
dc.identifier.startpage11en_US
dc.identifier.urihttps://doi.org/10.1016/j.msard.2017.04.006
dc.identifier.urihttps://hdl.handle.net/11468/15881
dc.identifier.volume15en_US
dc.identifier.wosWOS:000405050000004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofMultiple Sclerosis and Related Disorders
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMultiple Sclerosisen_US
dc.subjectAdipokineen_US
dc.subjectDisabilityen_US
dc.subjectAdiponectinen_US
dc.subjectMcp-1en_US
dc.subjectTnf-Alphaen_US
dc.titleInvestigation of the prognostic value of adipokines in multiple sclerosisen_US
dc.titleInvestigation of the prognostic value of adipokines in multiple sclerosis
dc.typeArticleen_US

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