The effects of pomegranate on bacterial translocation in rats with obstructive jaundice

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dc.contributor.authorGumus, M.
dc.contributor.authorTekin, R.
dc.contributor.authorFirat, U.
dc.contributor.authorOnder, A.
dc.contributor.authorKapan, M.
dc.contributor.authorBoyuk, A.
dc.contributor.authorAldemir, M.
dc.date.accessioned2024-04-24T17:38:24Z
dc.date.available2024-04-24T17:38:24Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractBACKGROUND: Obstructive jaundice may promote bacterial overgrowth and altered intestinal barrier function, with resultant increased bacterial translocation. AIMS: This study aimed to evaluate potential effects of pomegranate on bacterial translocation after bile duct ligation in rats. MATERIALS AND METHODS: Wistar albino rats were randomized into four groups. Group 1 underwent sham operation; Group 2 underwent sham operation and simultaneous treatment with pomegranate; Group 3 underwent common bile duct ligation, and Group 4 underwent common bile duct ligation and simultaneous treatment with pomegranate. After 8 days, the samples of systemic blood, liver, spleen and mesenteric lymph nodes (MLNs) were obtained under sterile conditions for microbiological culture. The segments of the ileum were removed for histopathological examination. RESULTS: Bacterial translocation significantly decreased in Group 4 compared to Group 3 (p = 0.007). The bacterial counts (Colony forming unit: CFU/g) of Group 3 were significantly higher than those of Groups 1, 2 and 4 (p < 0.05). The mean ileal villus heights in the Groups 1, 2, 3 and 4 were 480.5 +/- 20.5 mu m, 494.7 +/- 17.3 mu m, 356.3 +/- 25.7 mu m and 420.7 +/- 23.7 mu m, respectively. The mean villus height in Group 4 was higher than that of Group 3 (p = 0.010). CONCLUSIONS: Pomegranate has significant protective effects on intestinal mucosa barrier in obstructive jaundice and reduces bacterial translocation.en_US
dc.identifier.endpage1494en_US
dc.identifier.issn1128-3602
dc.identifier.issue11en_US
dc.identifier.pmid23771537
dc.identifier.scopus2-s2.0-84883466746
dc.identifier.scopusqualityQ2
dc.identifier.startpage1488en_US
dc.identifier.urihttps://hdl.handle.net/11468/21434
dc.identifier.volume17en_US
dc.identifier.wosWOS:000324923500008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPomegranateen_US
dc.subjectBacterial Translocationen_US
dc.subjectIleal Villus Heightsen_US
dc.subjectObstructive Jaundiceen_US
dc.titleThe effects of pomegranate on bacterial translocation in rats with obstructive jaundiceen_US
dc.titleThe effects of pomegranate on bacterial translocation in rats with obstructive jaundice
dc.typeArticleen_US

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