Low-dose methotrexate use in idiopathic granulomatous mastitis: An alternative treatment method

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dc.authorid0000-0002-9178-7843en_US
dc.authorid0000-0002-4889-7473en_US
dc.contributor.authorKafadar, Mehmet Tolga
dc.contributor.authorBahadır, Mehmet Veysi
dc.contributor.authorGirgin, Sadullah
dc.date.accessioned2022-07-05T10:50:07Z
dc.date.available2022-07-05T10:50:07Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalıen_US
dc.description.abstractBackground: Idiopathic granulomatous mastitis (IGM) is a rare, recurrent and progressive breast disease with an unknown etiology. Patients with IGM will probably face stressful, time-consuming treatment procedures with side effects due to medications. There are different treatment modalities in clinical use including medical and surgical interventions. Objective: The aim of this study was to present the results of using the combination therapy of low-dose methotrexate (MTX) and steroid in IGM. Methods: Seventeen patients diagnosed with IGM and treated with MTX were included into the study. Low-dose MTX at 5 mg/week and 8 mg/day prednisone were given for 2-3 months. Results: After 2-3 months of treatment, 10 patients exhibited (58.5%) complete, 3 patients (17.6%) partial recovery, and no response to the treatment process was observed in 4 patients (23.5%). No side effects of MTX and recurrent events were noted in any of the patients. Conclusion: Low-dose MTX and prednisone treatment for IGM patients, who did not respond to steroids alone, should be considered as an alternative treatment method instead of surgical intervention.en_US
dc.identifier.citationKafadar, M. T., Bahadır, M. V. ve Girgin, S. (2021). Low-dose methotrexate use in idiopathic granulomatous mastitis: An alternative treatment method. Breast Care, 16(4). 402-407.en_US
dc.identifier.doi10.1159/000513879en_US
dc.identifier.endpage407en_US
dc.identifier.issn1661-3791
dc.identifier.issue4en_US
dc.identifier.pmid34602947en_US
dc.identifier.scopus2-s2.0-85100009799en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage402en_US
dc.identifier.urihttps://www.karger.com/Article/FullText/513879
dc.identifier.urihttps://hdl.handle.net/11468/10114
dc.identifier.volume16en_US
dc.identifier.wosWOS:000612501800001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKafadar, Mehmet Tolga
dc.institutionauthorBahadlr, Mehmet Veysi
dc.institutionauthorGirgin, Sadullah
dc.language.isoenen_US
dc.publisherS. Karger AGen_US
dc.relation.ispartofBreast Careen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIdiopathic granulomatous mastitisen_US
dc.subjectMethotrexateen_US
dc.subjectTreatmenten_US
dc.titleLow-dose methotrexate use in idiopathic granulomatous mastitis: An alternative treatment methoden_US
dc.typeArticleen_US

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