Effects of Nicotine on Rat Alveolar Bone

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dc.contributor.authorEratilla, Veysel
dc.contributor.authorUysal, Ibrahim
dc.contributor.authorOzevren, Huseyin
dc.contributor.authorUysal, Rojdan Ferman Gunes
dc.contributor.authorAktas, Elif Eratilla
dc.contributor.authorKarabulut, Ozlen
dc.contributor.authorDeveci, Engin
dc.date.accessioned2024-04-24T17:33:42Z
dc.date.available2024-04-24T17:33:42Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: To investigate the effects of nicotine on periodontal membranes and alveolar bone using histopathological and immunohistochemical methods. STUDY DESIGN: Rats were divided into 2 groups: those systemically treated with nicotine sulfate (2 mg/kg subcutaneously, daily) for 28 days, and untreated controls. We analyzed the distribution of osteonectin and osteopontin immunohistochemically, with antibodies, in the maxillary region. RESULTS: In the treatment group, resorption of alveolar bone and vascular dilation, bleeding, periodontal membrane degeneration, hyalinization, and necrosis were seen in some areas. Negative osteoblastic activity was observed in immunohistochemical analyses of collagen fibers in the periodontal membrane. CONCLUSION: In short- and long-term nicotine consumption, soft tissue and alveolar bone are negatively affected during cell proliferation. This phenomenon may lead to a delay in treatment of implantation.en_US
dc.identifier.endpage282en_US
dc.identifier.issn0884-6812
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85008702169
dc.identifier.scopusqualityQ4
dc.identifier.startpage277en_US
dc.identifier.urihttps://hdl.handle.net/11468/20811
dc.identifier.volume38en_US
dc.identifier.wosWOS:000387093200004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlveolar Boneen_US
dc.subjectAlveolar Bone Lossen_US
dc.subjectBone Sialoprotein 1en_US
dc.subjectCollagenen_US
dc.subjectNicotineen_US
dc.subjectOsteonectinen_US
dc.subjectOsteopontinen_US
dc.subjectPeriodontal Bone Lossen_US
dc.subjectPeriodontitisen_US
dc.subjectSmokingen_US
dc.titleEffects of Nicotine on Rat Alveolar Boneen_US
dc.titleEffects of Nicotine on Rat Alveolar Bone
dc.typeArticleen_US

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