Effects of Nicotine on Rat Alveolar Bone
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Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Sci Printers & Publ Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
OBJECTIVE: To investigate the effects of nicotine on periodontal membranes and alveolar bone using histopathological and immunohistochemical methods. STUDY DESIGN: Rats were divided into 2 groups: those systemically treated with nicotine sulfate (2 mg/kg subcutaneously, daily) for 28 days, and untreated controls. We analyzed the distribution of osteonectin and osteopontin immunohistochemically, with antibodies, in the maxillary region. RESULTS: In the treatment group, resorption of alveolar bone and vascular dilation, bleeding, periodontal membrane degeneration, hyalinization, and necrosis were seen in some areas. Negative osteoblastic activity was observed in immunohistochemical analyses of collagen fibers in the periodontal membrane. CONCLUSION: In short- and long-term nicotine consumption, soft tissue and alveolar bone are negatively affected during cell proliferation. This phenomenon may lead to a delay in treatment of implantation.
Açıklama
Anahtar Kelimeler
Alveolar Bone, Alveolar Bone Loss, Bone Sialoprotein 1, Collagen, Nicotine, Osteonectin, Osteopontin, Periodontal Bone Loss, Periodontitis, Smoking
Kaynak
Analytical and Quantitative Cytopathology and Histopathology
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
38
Sayı
5
