Effects of Nicotine on Rat Alveolar Bone

[ X ]

Tarih

2016

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Sci Printers & Publ Inc

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

OBJECTIVE: To investigate the effects of nicotine on periodontal membranes and alveolar bone using histopathological and immunohistochemical methods. STUDY DESIGN: Rats were divided into 2 groups: those systemically treated with nicotine sulfate (2 mg/kg subcutaneously, daily) for 28 days, and untreated controls. We analyzed the distribution of osteonectin and osteopontin immunohistochemically, with antibodies, in the maxillary region. RESULTS: In the treatment group, resorption of alveolar bone and vascular dilation, bleeding, periodontal membrane degeneration, hyalinization, and necrosis were seen in some areas. Negative osteoblastic activity was observed in immunohistochemical analyses of collagen fibers in the periodontal membrane. CONCLUSION: In short- and long-term nicotine consumption, soft tissue and alveolar bone are negatively affected during cell proliferation. This phenomenon may lead to a delay in treatment of implantation.

Açıklama

Anahtar Kelimeler

Alveolar Bone, Alveolar Bone Loss, Bone Sialoprotein 1, Collagen, Nicotine, Osteonectin, Osteopontin, Periodontal Bone Loss, Periodontitis, Smoking

Kaynak

Analytical and Quantitative Cytopathology and Histopathology

WoS Q Değeri

Q4

Scopus Q Değeri

Q4

Cilt

38

Sayı

5

Künye