Protective effect of ethyl pyruvate on amikacin-induced ototoxicity in rats

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dc.authorid0000-0002-2421-4842en_US
dc.contributor.authorDedeoğlu, Serkan
dc.contributor.authorAyral, Muhammed
dc.date.accessioned2023-04-06T10:52:41Z
dc.date.available2023-04-06T10:52:41Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kulak Burun ve Boğaz Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractOBJECTIVE: Amikacin (AMK) is a widely used antibiotic, but its ototoxic side effects limit its use. This study investigated the effects of ethyl pyruvate (EP). known for its antioxidant and anti-inflammatory effects, against AMK ototoxicity. MATERIALS AND METHODS: 32 Wistar albino rats (n: 8) were used in this study. To cause ototoxicity, AMK 600 mg/kg/day dose was applied intramuscularly for 14 days. EP was administered via ip at a dose of 50 mg/kg/day for 14 days. RESULTS: The Auditory Brainstem Responses (ABR) and Distortion Product Otoacoustic Emissions (DPOAE) tests were performed on the study's 0, 7, and 14 days. The results have shown that the hearing functions were significantly impaired with the AMK application. A significant improvement was observed in the AM-K+EP group. While total oxidant status (TOS), oxidative stress index (OSI), and malondialdehyde (MDA) levels were found to be significantly higher in the AMK group compared to the control group. total antioxidant status (TAS) level was found to be significantly lower. In the AM-K+EP group, on the other hand, deterioration in TOS, OSI, and MDA levels detected in the AMK group was not observed. No elevated pro-inflammatory cytokines, such as TNF-alpha, IL-1 beta, and IL-6 were present in the EP+AMK group, which were detected in the AMK group. CONCLUSIONS: Hearing tests and biochemical results show that ethyl pyruvate has protective effects against amikacin ototoxicity due to its antioxidant and anti-inflammatory effects.en_US
dc.identifier.citationDedeoğlu, S. ve Ayral, M. (2022). Protective effect of ethyl pyruvate on amikacin-induced ototoxicity in rats. European Review for Medical and Pharmacological Sciences, 26(7), 2460-2466.en_US
dc.identifier.endpage2466en_US
dc.identifier.issn1128-3602
dc.identifier.issue7en_US
dc.identifier.pmid35442461
dc.identifier.scopusScopusIdYok
dc.identifier.scopusqualityQ2
dc.identifier.startpage2460en_US
dc.identifier.urihttps://hdl.handle.net/11468/11621
dc.identifier.volume26en_US
dc.identifier.wosWOS:000789631600009
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAyral, Muhammed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review for Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmikacinen_US
dc.subjectOtotoxicityen_US
dc.subjectEthyle pyruvateen_US
dc.subjectAuditory brainstem responses (ABR)en_US
dc.subjectDistortion product otoacoustic emissions (DPOAE)en_US
dc.subjectTotal oxidant status (TOS)en_US
dc.subjectTotal antioxidant status (TAS)en_US
dc.subjectPro-inflammatory cytokinesen_US
dc.titleProtective effect of ethyl pyruvate on amikacin-induced ototoxicity in ratsen_US
dc.titleProtective effect of ethyl pyruvate on amikacin-induced ototoxicity in rats
dc.typeArticleen_US

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