Protective effects of recombinant human interleukin-10 on intestines of hypoxia-induced necrotizing enterocolitis in immature rats

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dc.contributor.authorÖztürk, H
dc.contributor.authorDokucu, AI
dc.contributor.authorÖgun, C
dc.contributor.authorBüyükbayram, H
dc.date.accessioned2024-04-24T16:24:08Z
dc.date.available2024-04-24T16:24:08Z
dc.date.issued2002
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground/Purpose: The role of cytokines in the pathogenesis of hemodynamic instability or tissue destruction in patients with necrotizing enterocolitis (NEC) remains undefined. The aim of this study was to determine the effects of recombinant human interleukin-102 (rhIL-10) on intestines of hypoxia-induced necrotizing enterocolitis in immature rats. Methods: The study was performed on 1-day-old Sprague Dawley rat pups. Group 1 (n = 8) served as nonhypoxic controls. Group 2 (untreated, n 11) rats were subjected to hypoxia-reoxygenation (H/O) and then were returned to their mothers. Group 3 (rhIL-10 treated, n = 10) rats were subjected to H/O, were returned to their mothers, and were treated with rhIL-10 (75 mug/kg subcutaneously) for the next 3 days. All animals were killed on day 4, and intestine specimens were obtained to determine the tissue level of malon-dialdehyde (MDA) and histologic changes. Results: The microscopic lesions in the untreated rats were virtually the same as those seen in neonatal NEC, with destruction of villi and crypts, and in some cases extension to the muscularis. In contrast, in the rats treated with rhIL-10, lesions were limited essentially to the very tips of the villi. Intestinal injury score was significantly less in the rhIL-10-treated rats than in the untreated rats (P < .05). In the rhIL-10-treated group, Malondialdehyde (MDA) levels were not significant in comparison to the control group. In the untreated group, MDA levels were significantly increased when compared with the control and the rhIL-10-treated groups (P < .001 and P < .05, respectively). Conclusion: RhIL-10 has a protective effect on intestinal injury in NEC in an experimental model. Copyright 2002, Elsevier Science (USA). All rights reserved.en_US
dc.identifier.doi10.1053/jpsu.2002.35002
dc.identifier.endpage1333en_US
dc.identifier.issn0022-3468
dc.identifier.issue9en_US
dc.identifier.pmid12194126
dc.identifier.scopus2-s2.0-0036727784
dc.identifier.scopusqualityQ1
dc.identifier.startpage1330en_US
dc.identifier.urihttps://doi.org/10.1053/jpsu.2002.35002
dc.identifier.urihttps://hdl.handle.net/11468/16520
dc.identifier.volume37en_US
dc.identifier.wosWOS:000177881400016
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherW B Saunders Coen_US
dc.relation.ispartofJournal of Pediatric Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIntestinal Ischemiaen_US
dc.subjectNecrotizing Enterocolitisen_US
dc.subjectCytokineen_US
dc.subjectInterleukin-10en_US
dc.titleProtective effects of recombinant human interleukin-10 on intestines of hypoxia-induced necrotizing enterocolitis in immature ratsen_US
dc.titleProtective effects of recombinant human interleukin-10 on intestines of hypoxia-induced necrotizing enterocolitis in immature rats
dc.typeArticleen_US

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