Combining platelet rich fibrin with different bone graft materials: An experimental study on the histopathological and immunohistochemical aspects of bone healing

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dc.contributor.authorKarayurek, Fatih
dc.contributor.authorKadiroglu, Ela Tules
dc.contributor.authorNergiz, Yusuf
dc.contributor.authorAkcay, Neslihan Coskun
dc.contributor.authorTunik, Selcuk
dc.contributor.authorKanay, Berna Ersoz
dc.contributor.authorUysal, Ersin
dc.date.accessioned2024-04-24T16:15:02Z
dc.date.available2024-04-24T16:15:02Z
dc.date.issued2019
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: The current study was based on the hypothesis that the use of PRF with bone graft materials might increase bone regeneration and focus on the histopathological and immunohistochemical aspects following application of PRF with autogenous graft, xenograft and B-TCP in a rabbit model. Material and methods: This study was performed on the twenty-eight male New Zealand divided into four group. Two defects with a diameter 10 mm were opened in calvarium. After PRF preparation, right defects were evaluated as empty defect or graft group, and left defects were evaluated as PRF test group. All animals were sacrificed at the end of 8 weeks and specimens were examined histopathologically and immunohistochemically. Results: The most superior histopathological results were obtained in the autograft group. The combination of beta-TCP-PRF could not provide superiority over the beta-TCP group. The immunohistochemical results showed that, in the PRF/BTCP group, the expression of osteopontin and osteonectin was relatively higher compared to the only-BTCP group. Conclusion: In terms of new bone formation, autograft combined with PRF yielded superior results but the combination of beta-TCP-PRF had no effect compared to the only-BTCP group. However, further experimental and clinical studies might be beneficial to clarify the exact mechanism and results of combining PRF with bone grafts on bone healing process. (C) 2019 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipDicle University [13-DH-69]en_US
dc.description.sponsorshipThis research was supported by Dicle University Scientific Research Projects Coordinator (Project number: 13-DH-69).en_US
dc.identifier.doi10.1016/j.jcms.2019.01.023
dc.identifier.endpage825en_US
dc.identifier.issn1010-5182
dc.identifier.issn1878-4119
dc.identifier.issue5en_US
dc.identifier.pmid30765247
dc.identifier.scopus2-s2.0-85061329456
dc.identifier.scopusqualityQ1
dc.identifier.startpage815en_US
dc.identifier.urihttps://doi.org/10.1016/j.jcms.2019.01.023
dc.identifier.urihttps://hdl.handle.net/11468/15610
dc.identifier.volume47en_US
dc.identifier.wosWOS:000465162500015
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofJournal of Cranio-Maxillofacial Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBoneen_US
dc.subjectHistopathologicalen_US
dc.subjectImmunohistochemistryen_US
dc.subjectPlatelet Rich Fibrinen_US
dc.subjectRabbiten_US
dc.titleCombining platelet rich fibrin with different bone graft materials: An experimental study on the histopathological and immunohistochemical aspects of bone healingen_US
dc.titleCombining platelet rich fibrin with different bone graft materials: An experimental study on the histopathological and immunohistochemical aspects of bone healing
dc.typeArticleen_US

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