The Role of Apelins in the Physiology of the Heart

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dc.contributor.authorAydin, Suna
dc.contributor.authorEren, Mehmet Nesimi
dc.contributor.authorSahin, Ibrahim
dc.contributor.authorAydin, Suleyman
dc.date.accessioned2024-04-24T17:39:58Z
dc.date.available2024-04-24T17:39:58Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractApelins are a peptide hormone known as the ligand for the G protein-coupled APJ receptor. There are many different forms of apelin in the circulation. Apelins and their receptors are expressed in the central nervous system, including the hypothalamus, and in numerous other peripheral tissues. These peptides are also synthesized in and secreted from the adipose tissues. Additionally, apelins were immunohistochemically shown to be synthesized in smooth muscle cells in the media of the left internal mammary artery (LIMA) and the saphenous vein, fibroblast cells in the media of the aorta and endothelial cells of the intima. Similarly, it was recently reported that the enzyme linked immunoassay (ELISA) measurements of apelins were similar to its immunohistochemical data in the tissues of the aorta and left internal mammary artery. Apelins which are rapidly eliminated from the circulation have a half life of less than eight minutes. The normal concentration of apelins in the human plasma ranges between 1.3 ng/mL and 246 +/- 0.045 ng/mL. Apelins serve important functions in food intake, vasopressin (anti-diuretic hormone: ADH) and histamine release, gastric acid, bicarbonate secretion and insulin secretion, diuresis, cell proliferation, angiogenesis, glucose-fluid balance and regulation of gastrointestinal motility and cardiovascular system. Therefore, this review aims to focus on the potential role of the apelin system in the balance of the cardiovascular system.en_US
dc.identifier.endpage9en_US
dc.identifier.issn0929-8665
dc.identifier.issn1875-5305
dc.identifier.issue1en_US
dc.identifier.pmid23909376
dc.identifier.scopus2-s2.0-84891419887
dc.identifier.scopusqualityQ3
dc.identifier.startpage2en_US
dc.identifier.urihttps://hdl.handle.net/11468/21476
dc.identifier.volume21en_US
dc.identifier.wosWOS:000329022400002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofProtein and Peptide Letters
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApelinsen_US
dc.subjectCardiovascular Systemen_US
dc.subjectFluid Homeostasisen_US
dc.subjectPeptidesen_US
dc.titleThe Role of Apelins in the Physiology of the Hearten_US
dc.titleThe Role of Apelins in the Physiology of the Heart
dc.typeArticleen_US

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