Efficacy of azithromycin dihydrate in treatment of cryptosporidiosis in naturally infected dairy calves

Basit Öğe Kaydı
dc.contributor.authorElitok, E
dc.contributor.authorElitok, ÖM
dc.contributor.authorPulat, H
dc.date.accessioned2024-04-24T17:33:46Z
dc.date.available2024-04-24T17:33:46Z
dc.date.issued2005
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe objective of this study was to evaluate the therapeutic efficacy of azithromycin treatment of cryptosporidiosis in naturally infected calves under field conditions. Fifty Holstein calves with cryptosporidiosis infection were divided into 5 groups: I group (10 calves) was unmedicated and served as the control group and was given distilled water only, whereas the other groups (10 animals per group) were medicated orally with azithromycin at the doses of 500 (group 1), 1,000 (group 2), 1,500 (group 3), and 2,000 mg (group 4) PO once daily for 7 days. The animals were examined clinically and fecal samples were collected on the 1st (inclusion day), 7th, 14th, and 21st days of the study. Drug efficacy was assessed by evaluating diarrhea, oocyst shedding, and weight gains from days 1 to 21 (4 assessments). Significant differences were observed in reductions of oocyst shedding (P < .05) and the fecal diarrhea incidence (P < .05) in groups 3 and 4 when compared with groups I and 2 and the control group. Weight gain of medicated calves was significantly higher than that of the unmedicated calves throughout the study (P < .05). The drug significantly suppressed oocyst shedding and resulted in significant improvements in clinical signs. Therefore, this suppression may have significant effect on the reduction of environmental contamination by cryptosporidial oocysts. From the economic point view, authors suggest that the most effective dose of azithromycin for the treatment of cryptosporidiosis in calves should be at 1,500 mg/d for 7 days.en_US
dc.identifier.endpage593en_US
dc.identifier.issn0891-6640
dc.identifier.issn1939-1676
dc.identifier.issue4en_US
dc.identifier.pmid16095179
dc.identifier.scopus2-s2.0-23744505461
dc.identifier.scopusqualityQ1
dc.identifier.startpage590en_US
dc.identifier.urihttps://hdl.handle.net/11468/20834
dc.identifier.volume19en_US
dc.identifier.wosWOS:000230800000017
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Veterinary Internal Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAzithromycinen_US
dc.subjectCattleen_US
dc.subjectPathogenen_US
dc.subjectProtozoanen_US
dc.subjectTherapyen_US
dc.titleEfficacy of azithromycin dihydrate in treatment of cryptosporidiosis in naturally infected dairy calvesen_US
dc.titleEfficacy of azithromycin dihydrate in treatment of cryptosporidiosis in naturally infected dairy calves
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu