Clinical characteristics and treatment outcomes in 132 patients with malignant mesothelioma

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dc.contributor.authorAbakay, Abdurrahman
dc.contributor.authorTanrikulu, Abdullah C.
dc.contributor.authorKaplan, Muhammet Ali
dc.contributor.authorKucukoner, Mehmet
dc.contributor.authorAbakay, Ozlem
dc.contributor.authorSen, Hadice
dc.contributor.authorIsikdogan, Abdurrahman
dc.date.accessioned2024-04-24T17:24:13Z
dc.date.available2024-04-24T17:24:13Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose: Our objective is to scrutinize clinical, laboratory, radiological characteristics, treatment regimens, and treatment outcomes of malignant mesothelioma (MM) cases in our hospital. Materials and Methods: We investigated, retrospectively, the clinical characteristics and treatment outcomes of all 132 MM patients at Dicle University Hospital between January 2006 and April 2010. Results: A total of 82 (62.1%) patients were male, and 50 (37.9%) female. Median age was 56.0 years. Mean survival time was 9.66.9 months. Mean survival time of patients who had received best supportive care was 7.5 months, chemotherapy 10.4 months, and multimodality treatment regimen 12.6 months. Patients in the multimodality treatment group survived longer than did those in the other two groups (P=0.042). A total of 76 patients received chemotherapy, of whom 17 (22.3%) were administered Cisplatin/Carboplatin and Gemcitabine, 58 (76.4%) Cisplatin/Carboplatin and Pemetrexed, and one (1.3%) Cisplatin Docetaxel. Complete and partial response to treatment in patients receiving Cisplatin/Carboplatin and Gemcitabine was found 47.1% and Cisplatin/Carboplatin and Pemetrexed was found 50.0% (P>0.05). Conclusions: MM related to asbestos exposure is seen frequently in Turkey. Patients present with the typical clinical features of dyspnea, weight loss, and chest pain. Survival analysis shows that patients receiving multimodality treatment may be better.en_US
dc.identifier.doi10.4103/0970-2113.85688
dc.identifier.endpage271en_US
dc.identifier.issn0970-2113
dc.identifier.issn0974-598X
dc.identifier.issue4en_US
dc.identifier.pmid22084540
dc.identifier.scopus2-s2.0-80055024607
dc.identifier.scopusqualityQ3
dc.identifier.startpage267en_US
dc.identifier.urihttps://doi.org/10.4103/0970-2113.85688
dc.identifier.urihttps://hdl.handle.net/11468/19528
dc.identifier.volume28en_US
dc.identifier.wosWOS:000219341600008
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherMedknow Publications & Media Pvt Ltden_US
dc.relation.ispartofLung India
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAsbestosen_US
dc.subjectChemotherapyen_US
dc.subjectLung Canceren_US
dc.subjectMesotheliomaen_US
dc.titleClinical characteristics and treatment outcomes in 132 patients with malignant mesotheliomaen_US
dc.titleClinical characteristics and treatment outcomes in 132 patients with malignant mesothelioma
dc.typeArticleen_US

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