Elevated serum levels of calprotectin (MRP8/MRP14) in patients with Behcet's disease and its association with disease activity and quality of life

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dc.contributor.authorOktayoglu, Pelin
dc.contributor.authorMete, Nuriye
dc.contributor.authorCaglayan, Mehmet
dc.contributor.authorBozkurt, Mehtap
dc.contributor.authorBozan, Turgut
dc.contributor.authorEm, Serda
dc.contributor.authorNas, Kemal
dc.date.accessioned2024-04-24T17:20:25Z
dc.date.available2024-04-24T17:20:25Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground. Behcet's disease (BD) is an inflammatory disease with multisystem chronic vasculitis. The disease is characterized by attacks of oral and genital ulcerations, skin lesions, arthritis, uveitis and deep vein thrombosis. The main histopathological feature is known to be vascular inflammatory change. Calprotectin (MRP8/MRP14) has been identified as an important alarmin that is expressed by activated phagocytes, granulocytes, monocytes and vascular endothelial cells, recognized by toll-like receptors, and induces a thrombogenic and inflammatory response in human microvascular endothelial cells. Aim. We aimed to investigate the serum levels of calprotectin in patients with BD and its association with disease activity and quality of life. Materials and methods. Forty-eight patients (25 males and 23 females) and 47 healthy controls (29 males and 18 females) were included to study. BD Current Activity Form (BDCAF) was used to assess the disease activity of patients with BD. Quality of life was assessed by using the Nottingham Health Profile (NHP). Depression and anxiety symptoms were assessed by using the Hospital Anxiety and Depression Scale (HADS). Serum level of calprotectin was determined using an ELISA kit. Results. Serum levels of calprotectin was significantly higher in patients with BD compared to healthy controls (p = 0.001). Serum levels of calprotectin did not correlate with the sores of BDCAF, NHP and HADS. Conclusion. Calprotectin may play a significant role in the pathogenetic mechanisms of BD. Further insight into this area of research might provide opportunities to develop novel treatment strategies.en_US
dc.identifier.doi10.3109/00365513.2014.984319
dc.identifier.endpage112en_US
dc.identifier.issn0036-5513
dc.identifier.issn1502-7686
dc.identifier.issue2en_US
dc.identifier.pmid25471894
dc.identifier.scopus2-s2.0-84924338815
dc.identifier.scopusqualityQ3
dc.identifier.startpage106en_US
dc.identifier.urihttps://doi.org/10.3109/00365513.2014.984319
dc.identifier.urihttps://hdl.handle.net/11468/19041
dc.identifier.volume75en_US
dc.identifier.wosWOS:000350543700002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofScandinavian Journal of Clinical & Laboratory Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBehcet Diseaseen_US
dc.subjectCalprotectinen_US
dc.subjectInflammationen_US
dc.subjectDisease Activityen_US
dc.subjectQuality Of Lifeen_US
dc.titleElevated serum levels of calprotectin (MRP8/MRP14) in patients with Behcet's disease and its association with disease activity and quality of lifeen_US
dc.titleElevated serum levels of calprotectin (MRP8/MRP14) in patients with Behcet's disease and its association with disease activity and quality of life
dc.typeArticleen_US

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