Comparison of local rosmarinic acid and topical dexpanthenol applications on wound healing in a rat experimental wound model

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dc.authorid0000-0001-7317-5467en_US
dc.authorid0000-0001-7203-2288en_US
dc.contributor.authorKüba, M. C.
dc.contributor.authorTürkoǧlu, Ahmet
dc.contributor.authorOğuz, Abdullah
dc.contributor.authorTuncer, Cudi Mehmet
dc.contributor.authorKaya, Suheyla
dc.contributor.authorBaşol, Ömer
dc.contributor.authorBilge, Hüseyin
dc.contributor.authorTatlı, Faruk
dc.date.accessioned2022-03-16T07:09:21Z
dc.date.available2022-03-16T07:09:21Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalıen_US
dc.descriptionPMID: 32844390
dc.descriptionWOS:000695506700017
dc.description.abstractBackground: The aim of the study was to compare the effects of rosmarinic acid and dexpanthenol in a rat experimental wound model. Materials and methods: Twenty-four Wistar albino rats weighing 200-250 g were randomly divided into three groups. After 2-cm full-thickness skin defects were created, the wounds were washed with sterile 0.9% NaCl solution. After washing, the control group was left untreated, the second group received 5% dexpanthenol cream, and the third group received 10% rosmarinic acid cream. Before excision, the skin was evaluated macroscopically by measuring the reduction in wound size; after excision, histological examination (epithelisation, inflammation, fibrosis, granulation) was performed. Results: Macroscopic comparison of the wound sizes showed that group 3 showed a statistically significant difference in wound size reduction compared to the other two groups. Histopathological examination showed that there was no statistically significant difference between the groups. We found that the rosmarinic acid group had greater wound size reduction than the other two groups. However, epithelialisation was detected in fewer cases. Conclusions: We believe that rosmarinic acid can be used as a topical cream for wound healing, as it leads to significant reduction in wound size, resulting in fewer scars.en_US
dc.identifier.citationKüba, M. C., Türkoǧlu, A., Oğuz, A., Tuncer, C. M., Kaya, S., Başol, Ö. ve diğerleri. (2021). Comparison of local rosmarinic acid and topical dexpanthenol applications on wound healing in a rat experimental wound model. Folia Morphologica, 80(3), 618-624.en_US
dc.identifier.doi10.5603/FM.a2020.0097
dc.identifier.endpage624en_US
dc.identifier.issn0015-5659
dc.identifier.issue3en_US
dc.identifier.pmid32844390
dc.identifier.scopus2-s2.0-85115204478
dc.identifier.scopusqualityQ2
dc.identifier.startpage618en_US
dc.identifier.urihttps://journals.viamedica.pl/folia_morphologica/article/view/69409
dc.identifier.urihttps://hdl.handle.net/11468/9447
dc.identifier.volume80en_US
dc.identifier.wosWOS:000695506700017
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorOǧuz, Abdullah
dc.institutionauthorTuncer, Cudi Mehmet
dc.institutionauthorBaşol, Ömer
dc.institutionauthorBilge, Hüseyin
dc.institutionauthorTatlı, Faruk
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofFolia Morphologica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDexpanthenolen_US
dc.subjectRaten_US
dc.subjectRosmarinic aciden_US
dc.subjectWound healingen_US
dc.titleComparison of local rosmarinic acid and topical dexpanthenol applications on wound healing in a rat experimental wound modelen_US
dc.titleComparison of local rosmarinic acid and topical dexpanthenol applications on wound healing in a rat experimental wound model
dc.typeArticleen_US

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