Antioxidant support in composite musculo-adipose-fasciocutaneous flap applications: An experimental study

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dc.contributor.authorBozkurt, Mehmet
dc.contributor.authorKapi, Emin
dc.contributor.authorKulahci, Yalcin
dc.contributor.authorGedik, Ercan
dc.contributor.authorOzekinci, Selver
dc.contributor.authorIsik, Fatma Birgul
dc.contributor.authorCelik, Yusuf
dc.date.accessioned2024-04-24T17:20:36Z
dc.date.available2024-04-24T17:20:36Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractFree radicals are chemicals that play roles in the etio-pathogenesis of ischaemia-reperfusion injury. Various antioxidants have been used in an attempt to mitigate the damage induced by these chemicals. In the present study, the antioxidative effects of grape seed extract (proanthocyanidin), tomato extract (lycopene), and vitamin C (ascorbic acid) on a composite re-established-flow inferior epigastric artery based rectus abdominis muscle-skin flap model on which experimental ischaemia was induced were investigated. The rats have been administered antioxidants for 2 weeks prior to the surgery and for 2 more weeks thereafter. Macroscopic, histopathological, and biochemical analyses were carried out at the decision of the experiment. It was found that flap skin island necrosis was significantly reduced in the proanthocyanidin, lycopene, vitamin C groups (p < 0.001). Statistical analyses showed significant decreases in inflammation, oedema, congestion, and granulation tissue in the proanthocyanidin and lycopene groups compared to the vitamin C and control groups (p < 0.001). When the viability rates of fat and muscle tissues were examined, significant improvements were found in the proanthocyanidin and lycopene groups in comparison to the other groups (p < 0.001). Serum antioxidant capacity measurements revealed significant differences in the lycopene group compared to all other groups (p < 0.001). It is concluded that lycopene and proanthocyanidin are protective antioxidants in rat composite muscle-skin flap ischaemia-reperfusion models.en_US
dc.identifier.doi10.3109/2000656X.2013.800527
dc.identifier.endpage50en_US
dc.identifier.issn2000-656X
dc.identifier.issn2000-6764
dc.identifier.issue1en_US
dc.identifier.pmid23731129
dc.identifier.scopus2-s2.0-84892631121
dc.identifier.scopusqualityQ2
dc.identifier.startpage44en_US
dc.identifier.urihttps://doi.org/10.3109/2000656X.2013.800527
dc.identifier.urihttps://hdl.handle.net/11468/19154
dc.identifier.volume48en_US
dc.identifier.wosWOS:000329857200010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Plastic Surgery and Hand Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidanten_US
dc.subjectFlapsen_US
dc.subjectRectus Abdominisen_US
dc.subjectProanthocyanidinen_US
dc.subjectLycopeneen_US
dc.subjectVitamin Cen_US
dc.titleAntioxidant support in composite musculo-adipose-fasciocutaneous flap applications: An experimental studyen_US
dc.titleAntioxidant support in composite musculo-adipose-fasciocutaneous flap applications: An experimental study
dc.typeArticleen_US

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