Mean platelet volume in predicting short- and long-term morbidity and mortality in patients with or without ST-segment elevation myocardial infarction

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dc.contributor.authorTekbas, Ebru
dc.contributor.authorKara, Ali F.
dc.contributor.authorAriturk, Zuhal
dc.contributor.authorCil, Habib
dc.contributor.authorIslamoglu, Yahya
dc.contributor.authorElbey, Mehmet A.
dc.contributor.authorSoydinc, Serdar
dc.date.accessioned2024-04-24T17:20:25Z
dc.date.available2024-04-24T17:20:25Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractMean platelet volume (MPV) is a marker of platelet activation. An increased MPV is associated with acute myocardial infarction (AMI) and long-term mortality. The aim of this study was to compare MPV in patients with ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI). Also, we investigated the value of MPV on in-hospital mortality and long-term prognosis of patients with STEMI and NSTEMI. We studied 429 patients with AMI (70.4% male, 61.9 +/- 12.4 years; 279 patients with STEMI, 150 patients with NSTEMI). MPV and platelet count were similar in both groups. Elevated MPV increased the risk of death by 3.1-fold (p < 0.001) in STEMI group during the hospitalization. However, increased MPV was not associated with in-hospital mortality in NSTEMI group. The area under the receiver operating characteristic curve of MPV was 0.868 (95% CI, 0.830-0.907) for predicting two-year mortality. A cut-off point of 11.1 fL showed a sensitivity of 81% and a specifity of 77% for prediction of two-year mortality. Kaplan-Meier survival curve showed two-year mortality rate of 12.5% in patients with MPV > 11.1 fL versus 9.9% in patients with MPV < 11.1 fL (p < 0.001). Cox regression analysis showed MPV to be an independent predictor of two-year mortality (Hazard ratio 1.7; 95% CI 1.5-1.9; p < 0.001). An increased MPV is an independent predictor of in-hospital mortality in patients with STEMI. However, elevated levels of MPV did not predict in hospital mortality in NSTEMI group. The increase in MPV values was independently correlated with two-year mortality in all study patients.en_US
dc.identifier.doi10.3109/00365513.2011.599416
dc.identifier.endpageU102en_US
dc.identifier.issn0036-5513
dc.identifier.issue7en_US
dc.identifier.pmid21859357en_US
dc.identifier.scopus2-s2.0-80054089284en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage613en_US
dc.identifier.urihttps://doi.org/10.3109/00365513.2011.599416
dc.identifier.urihttps://hdl.handle.net/11468/19040
dc.identifier.volume71en_US
dc.identifier.wosWOS:000295799300013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofScandinavian Journal of Clinical & Laboratory Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Myocardial Infarctionen_US
dc.subjectMean Platelet Volumeen_US
dc.subjectPlateletsen_US
dc.subjectPrognosisen_US
dc.subjectSurvivalen_US
dc.titleMean platelet volume in predicting short- and long-term morbidity and mortality in patients with or without ST-segment elevation myocardial infarctionen_US
dc.typeArticleen_US

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