New inflammatory markers in pre-eclampsia: echocardiographic epicardial fat thickness and neutrophil to lymphocyte ratio

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dc.contributor.authorOylumlu, Mustafa
dc.contributor.authorOzler, Ali
dc.contributor.authorYildiz, Abdulkadir
dc.contributor.authorOylumlu, Muhammed
dc.contributor.authorAcet, Halit
dc.contributor.authorPolat, Nihat
dc.contributor.authorSoydinc, Hatice Ender
dc.date.accessioned2024-04-24T17:20:31Z
dc.date.available2024-04-24T17:20:31Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Increased epicardial fat thickness (EFT) has been proposed as a new cardiometabolic risk factor. The neutrophil/lymphocyte ratio (NLR) has predictive and prognostic value in several cardiovascular diseases. The aim of this study was to explore the association between EFT and NLR in patients with pre-eclampsia. Methods: Hundred and eight pregnant patients with a mean age of 30.6 +/- 6.3 years were included in the study. Patients were divided into two groups based on the presence of pre-eclampsia. All participants underwent transthoracic echocardiography imaging, and complete blood counts were measured by an automated hematology analyzer. Statistical analysis was performed using the Chi-square, Mann-Whitney U, correlation and logistic regression tests, and receiver operating characteristic (ROC) analysis. Result: The mean EFT value of the pre-eclampsia group was significantly higher than the control group (6.9 +/- 0.6 versus 5.6 +/- 0.6; p < 0.001), and the NLR value of the pre-eclampsia group was also significantly higher than the control group (7.3 +/- 3.5 versus 3.1 +/- 1.1; p < 0.001). Multivariate analysis showed that increased levels of NLR and echocardiographic EFT are independent predictors of pre-eclampsia. In the receiver operating characteristic analysis, a level of EFT >= 6.2 mm and NLR >= 4.1 predicted the presence of pre-eclampsia with 77.8% sensitivity, 79.6% specificity and 83.3% sensitivity, 81.5% specificity, respectively. Conclusion: Unlike many other inflammatory markers and bioassays, NLR and echocardiographic EFT are inexpensive and readily available biomarkers that may be useful for risk stratification in patients with pre-eclampsia.en_US
dc.description.sponsorshipDicle University DUBAPen_US
dc.description.sponsorshipWe are grateful to Dicle University DUBAP for their sponsorship about English editing of this manuscript.en_US
dc.identifier.doi10.3109/10641963.2013.863324
dc.identifier.endpage507en_US
dc.identifier.issn1064-1963
dc.identifier.issn1525-6006
dc.identifier.issue7en_US
dc.identifier.pmid24433091en_US
dc.identifier.scopus2-s2.0-84908623912en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage503en_US
dc.identifier.urihttps://doi.org/10.3109/10641963.2013.863324
dc.identifier.urihttps://hdl.handle.net/11468/19108
dc.identifier.volume36en_US
dc.identifier.wosWOS:000344603300011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofClinical and Experimental Hypertensionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEchocardiographyen_US
dc.subjectEpicardial Fat Thicknessen_US
dc.subjectHypertensionen_US
dc.subjectNeutrophil To Lymphocyte Ratioen_US
dc.subjectPre-Eclampsiaen_US
dc.titleNew inflammatory markers in pre-eclampsia: echocardiographic epicardial fat thickness and neutrophil to lymphocyte ratioen_US
dc.typeArticleen_US

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