The correlation between adiposity and adiponectin tumor necrosis factor ?, interleukin-6 and high sensitivity C-reactive protein levels.: Is adipocyte size asssociated with inflammation in adults?

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dc.contributor.authorBahceci, M.
dc.contributor.authorGokalp, D.
dc.contributor.authorBahceci, S.
dc.contributor.authorTuzcu, A.
dc.contributor.authorAtmaca, S.
dc.contributor.authorArikan, S.
dc.date.accessioned2024-04-24T15:59:41Z
dc.date.available2024-04-24T15:59:41Z
dc.date.issued2007
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Hypertrophic obesity correlates with metabolic complications of obesity. We evaluated adipocyte volume and its relationship with tumor necrosis factor ct (TNF-ct), interleukin-6 (IL-6), adiponectin and high sensitivity C-reactive protein (hs-CRP) levels. Subjects and methods: Patients were divided into 4 groups; lean healthy controls [body mass index (BMI): 24.2 +/- 1.4 kg/m(2)], non-diabetic obese patients (30.2 +/- 2.9), obese (30.1 +/- 3.2) and non-obese (22.2 +/- 11.5) Type 2 diabetic patients. TNF-a., hs-CRP, adiponectin and IL-6 levels were measured preoperatively and sc fat specimens were obtained during operation. Semi-thin sections were stained with toluidine-blue and evaluated by light microscopy. Fat volumes were calculated by Goldrick's formulation. Results: Mean adipocyte volumes were higher in obese diabetic patients than in other groups (p<0.0001). Mean TNF-alpha, hs-CRP and IL-6 levels were higher in obese diabetic patients than in control subjects, obese non-diabetic and non-obese diabetic patients (p<0.0001, p<0.02 and p<0.01, respectively). Mean TNF-alpha levels of non-diabetic obese patients were higher than the control group (p<0.05). Mean IL-6 levels of diabetic and non-diabetic obese patients were higher than control subjects (p<0.02 and p<0.0001, respectively). Mean adiponectin levels of control subjects were higher than non-diabetic obese, non-obese diabetic and obese-diabetic subjects (p<0.0001). Mean adiponectin levels of obese diabetic patients were lower than non-diabetic obese subjects (p<0.008). Mean hs-CRP levels were higher in diabetic patients whether they were obese or not. There was a positive correlation between adipocyte size and TNF-a. (p<0.01), IL-6 (p<0.03) and hs-CRP levels (p<0.004), and negative correlation between adipocyte size, adiponectin levels (p<0.0001). Conclusions: TNF-cc, IL-6 and hs-CRP levels were positively, adiponectin negatively correlated with adipocyte size. Therefore, adiposity may be an inflammatory condition.en_US
dc.identifier.doi10.1007/BF03347427
dc.identifier.endpage214en_US
dc.identifier.issn0391-4097
dc.identifier.issn1720-8386
dc.identifier.issue3en_US
dc.identifier.pmid17505154
dc.identifier.scopus2-s2.0-34250628015
dc.identifier.scopusqualityQ1
dc.identifier.startpage210en_US
dc.identifier.urihttps://doi.org/10.1007/BF03347427
dc.identifier.urihttps://hdl.handle.net/11468/14211
dc.identifier.volume30en_US
dc.identifier.wosWOS:000247015900007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Endocrinological Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTnf-Alphaen_US
dc.subjectIl-6en_US
dc.subjectHs-Crpen_US
dc.subjectAdiponectinen_US
dc.subjectAdipocyte Volumeen_US
dc.subjectObesityen_US
dc.subjectInflammationen_US
dc.titleThe correlation between adiposity and adiponectin tumor necrosis factor ?, interleukin-6 and high sensitivity C-reactive protein levels.: Is adipocyte size asssociated with inflammation in adults?en_US
dc.titleThe correlation between adiposity and adiponectin tumor necrosis factor ?, interleukin-6 and high sensitivity C-reactive protein levels.: Is adipocyte size asssociated with inflammation in adults?
dc.typeArticleen_US

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