Expression of pSTAT3 and TNF-? in Normotensive and Severe Preeclamptic Placentas

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dc.contributor.authorTogrul, Cihan
dc.contributor.authorGorkem, Umit
dc.contributor.authorIrtegun, Sevgi
dc.contributor.authorTahaoglu, Ali Emre
dc.contributor.authorGungor, Tayfun
dc.contributor.authorDeveci, Engin
dc.date.accessioned2024-04-24T17:33:56Z
dc.date.available2024-04-24T17:33:56Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: To examine histopathologic changes and correlation between TNF-alpha and pSTAT3 expression levels by western blot and immunohistochemical methods in preeclamptic placentas. STUDY DESIGN: Obstetrical properties and bio-chemical and hematological features of patients with preeclampsia and healthy subjects were compared. Paraffin sections obtained from placenta were stained with hematoxylin-eosin for histopathologic examination. RESULTS: In histopathologic examination of preeclamptic placentas, cytotrophoblastic cellular proliferation, fibrinoid necrosis, endothelial proliferation, and calcified and hyalinized villous spots were observed. CONCLUSION: In preeclamptic placentas, we observed that trophoblastic invasion may downregulate STAT3 phosphorylation and can correlate with TNF-alpha elevation. Even though trophoblast invasion may interfere with both vascular and immune systems, TNF-alpha is not directly involved in the STAT3 signaling pathway in the preeclamptic placenta. (Anal Quant Cytopathol Histpathol 2017; 39: 149-156)en_US
dc.identifier.endpage156en_US
dc.identifier.issn0884-6812
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85020546699
dc.identifier.scopusqualityQ4
dc.identifier.startpage149en_US
dc.identifier.urihttps://hdl.handle.net/11468/20894
dc.identifier.volume39en_US
dc.identifier.wosWOS:000404398300005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPlacentaen_US
dc.subjectPreeclampsiaen_US
dc.subjectStat3en_US
dc.subjectTnf-Alphaen_US
dc.titleExpression of pSTAT3 and TNF-? in Normotensive and Severe Preeclamptic Placentasen_US
dc.titleExpression of pSTAT3 and TNF-? in Normotensive and Severe Preeclamptic Placentas
dc.typeArticleen_US

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