Expression of pSTAT3 and TNF-? in Normotensive and Severe Preeclamptic Placentas
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Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Sci Printers & Publ Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
OBJECTIVE: To examine histopathologic changes and correlation between TNF-alpha and pSTAT3 expression levels by western blot and immunohistochemical methods in preeclamptic placentas. STUDY DESIGN: Obstetrical properties and bio-chemical and hematological features of patients with preeclampsia and healthy subjects were compared. Paraffin sections obtained from placenta were stained with hematoxylin-eosin for histopathologic examination. RESULTS: In histopathologic examination of preeclamptic placentas, cytotrophoblastic cellular proliferation, fibrinoid necrosis, endothelial proliferation, and calcified and hyalinized villous spots were observed. CONCLUSION: In preeclamptic placentas, we observed that trophoblastic invasion may downregulate STAT3 phosphorylation and can correlate with TNF-alpha elevation. Even though trophoblast invasion may interfere with both vascular and immune systems, TNF-alpha is not directly involved in the STAT3 signaling pathway in the preeclamptic placenta. (Anal Quant Cytopathol Histpathol 2017; 39: 149-156)
Açıklama
Anahtar Kelimeler
Placenta, Preeclampsia, Stat3, Tnf-Alpha
Kaynak
Analytical and Quantitative Cytopathology and Histopathology
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
39
Sayı
3
