The bioactive peptides salusins and apelin-36 are produced in human arterial and venous tissues and the changes of their levels during cardiopulmonary bypass

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dc.contributor.authorAydin, Suna
dc.contributor.authorEren, Mehmet Nesimi
dc.contributor.authorAydin, Suleyman
dc.contributor.authorOzercan, Ibrahim Hanefi
dc.contributor.authorDagli, Adile Ferda
dc.date.accessioned2024-04-24T16:15:48Z
dc.date.available2024-04-24T16:15:48Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis study aimed to examine the effects of CPB on salusin-alpha, salusin-beta and apelin-36 bioactive peptides in people who are planned to undergo coronary artery bypass graft (CABG) operation due to coronary artery disease and to explore whether these peptides are produced in human aortic, saphenous and arterial tissues. The study included age and BMI matched 15 patients who underwent CABG operation by CPB. In order to determine salusin-alpha, salusin-beta and apelin-36 levels, venous blood samples were collected before induction of anesthesia (T1), before CPB (T2), 5 min before the removal of cross-clamp (T3), 5 min after the removal of cross-clamp (14), upon arrival in the intensive care (15), at postoperative 24th hour (16) and 72nd hour (T7). Salusin and apelin expressions of the tissues were shown by immunohistochemical method. Peptide amounts of sera and tissues were measured using ELISA. Salusins production by vessels occurs in fibroblast cells of the media in the aorta and smooth muscle cells of the media in the LIMA and saphena. Apelin is produced by endothelial cells of the intima and fibroblast cells of the media in the aorta and by smooth muscle cells of the media in the LIMA and saphena. Changes in the levels of salusin-beta and apelin-36 were significant during CPB. Salusin-alpha, salusin-beta and apelin-36 are locally synthesized in the arteries and veins. Salusins and apelin-36 might be important markers in the CPB, and also that salusin-beta was more specific in comparison to salusin-alpha. (C) 2012 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipMustafa GURSEL; Mustafa AYDINen_US
dc.description.sponsorshipThe authors would like to extend their thanks to Mustafa GURSEL and Mustafa AYDIN for their financial support.en_US
dc.identifier.doi10.1016/j.peptides.2012.07.027
dc.identifier.endpage239en_US
dc.identifier.issn0196-9781
dc.identifier.issn1873-5169
dc.identifier.issue2en_US
dc.identifier.pmid22884920
dc.identifier.scopus2-s2.0-84865425142
dc.identifier.scopusqualityQ2
dc.identifier.startpage233en_US
dc.identifier.urihttps://doi.org/10.1016/j.peptides.2012.07.027
dc.identifier.urihttps://hdl.handle.net/11468/15929
dc.identifier.volume37en_US
dc.identifier.wosWOS:000310047700007
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofPeptides
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSalusin-Alphaen_US
dc.subjectSalusin-Betaen_US
dc.subjectApelin-36en_US
dc.subjectBioactive Peptidesen_US
dc.subjectCoronary Artery Bypassen_US
dc.subjectLimaen_US
dc.subjectSaphenaen_US
dc.titleThe bioactive peptides salusins and apelin-36 are produced in human arterial and venous tissues and the changes of their levels during cardiopulmonary bypassen_US
dc.titleThe bioactive peptides salusins and apelin-36 are produced in human arterial and venous tissues and the changes of their levels during cardiopulmonary bypass
dc.typeArticleen_US

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