ASSESSMENT OF THE CARDIOTOXICITY OF TULATHROMYCIN IN RABBITS

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dc.contributor.authorEr, Ayse
dc.contributor.authorAltan, Feray
dc.contributor.authorCetin, Gul
dc.contributor.authorDik, Burak
dc.contributor.authorElmas, Muammer
dc.contributor.authorYazar, Enver
dc.date.accessioned2024-04-24T17:18:05Z
dc.date.available2024-04-24T17:18:05Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this study was to determine the cardiotoxic potency of tulathromycin. Tulathromycin (10 mg/kg, SC) was administered to ten adult male rabbits, and blood samples were obtained before and after drug administration (0 and 6 hours). Serum cardiac damage markers (troponin I, creatine kinase-MB, myoglobin, lactate dehydrogenase, aspartate aminotransferase), routine serum biochemical values (alkaline phosphatase, alanine aminotransferase, gammaglutamyltransferase, creatinine, blood urea nitrogen, cholesterol, triglyceride, high-density lipoprotein, amylase, total protein, albumin, glucose, calcium, ionised calcium, sodium, potassium), white blood cell (WBC) and red blood cell (RBC) counts, arterial blood gas parameters (pH, partial carbon dioxide pressure, partial oxygen pressure, actual bicarbonate, standard bicarbonate, total carbon dioxide, base excess in vivo, base excess in vitro, oxygen saturation, packed cell volume, haemoglobin) and serum oxidative status (malondialdehyde, nitric oxide, superoxide dismutase, retinol, beta-carotene) were measured. Increased levels of troponin I, creatine kinase-MB and creatinine, and decreased WBC counts, ionised calcium and potassium levels were observed after drug administration. Tulathromycin treatment may cause cardiotoxicity, but its effects may be less dramatic than those of other macrolide antibiotics frequently used in veterinary medicine.en_US
dc.identifier.doi10.1556/AVet.2011.015
dc.identifier.endpage335en_US
dc.identifier.issn0236-6290
dc.identifier.issn1588-2705
dc.identifier.issue3en_US
dc.identifier.pmid21727065
dc.identifier.scopus2-s2.0-79960285290
dc.identifier.scopusqualityQ2
dc.identifier.startpage327en_US
dc.identifier.urihttps://doi.org/10.1556/AVet.2011.015
dc.identifier.urihttps://hdl.handle.net/11468/18592
dc.identifier.volume59en_US
dc.identifier.wosWOS:000292467600005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherAkademiai Kiado Zrten_US
dc.relation.ispartofActa Veterinaria Hungarica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTulathromycinen_US
dc.subjectCardiotoxicityen_US
dc.titleASSESSMENT OF THE CARDIOTOXICITY OF TULATHROMYCIN IN RABBITSen_US
dc.titleASSESSMENT OF THE CARDIOTOXICITY OF TULATHROMYCIN IN RABBITS
dc.typeArticleen_US

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