Serum paraoxonase, TAS, TOS and ceruloplasmin in brucellosis

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dc.contributor.authorDemirpence, Ozlem
dc.contributor.authorSevim, Bunyamin
dc.contributor.authorYildirim, Mustafa
dc.contributor.authorNurlu, Nilhan Ayan
dc.contributor.authorMert, Duygu
dc.contributor.authorEvliyaoglu, Osman
dc.date.accessioned2024-04-24T17:38:03Z
dc.date.available2024-04-24T17:38:03Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractIt is possible that brucellosis may be related to increase free radical production and antioxidant depletion. Thus, in the present study we aimed to evaluate the oxidative status in patient with brucellosis and healthy controls. Methods: This study includes the patients with brucellosis diagnosed by clinical findings and positive agglutination titer. The paraoxonase, ceruloplasmin, total antioxidant capacity and total oxidant status values were measured from the samples taken. The oxidative stress index value was calculated through the total antioxidant capacity and total oxidant status values. Results: A total number of 93 people, 40 women (43%) and 53 men (57%) were included to the study. The levels of ceruloplasmin were found higher in patients when compared to the control group (p < 0.001). The total antioxidant capacity level was found significantly higher in the patients group when compared to the control group (p < 0.001). The oxidative stress index value was significantly lower in the patients group when compared to the control group (p < 0.001). The paraoxonase-1 level was not different in control and patient groups (p = 0.077). Conclusions: Brucellosis is an infection that is frequently seen in Mediterranean countries. This infection breaks the oxidant and antioxidant balance. In this disease, oxidant-antioxidant system indicators such as ceruloplasmin, total antioxidant capacity, total oxidant status and oxidative stress index can be used for showing the role of the brucella infection and for the monitoring of the treatment results.en_US
dc.identifier.endpage1597en_US
dc.identifier.issn1940-5901
dc.identifier.issue6en_US
dc.identifier.pmid25035784
dc.identifier.scopus2-s2.0-84904057795
dc.identifier.scopusqualityN/A
dc.identifier.startpage1592en_US
dc.identifier.urihttps://hdl.handle.net/11468/21305
dc.identifier.volume7en_US
dc.identifier.wosWOS:000341255900014
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal of Clinical and Experimental Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrucellaen_US
dc.subjectTotal Antioxidant Capacityen_US
dc.subjectTotal Oxidant Statusen_US
dc.subjectParaoxonaseen_US
dc.subjectCeruloplasminen_US
dc.titleSerum paraoxonase, TAS, TOS and ceruloplasmin in brucellosisen_US
dc.titleSerum paraoxonase, TAS, TOS and ceruloplasmin in brucellosis
dc.typeArticleen_US

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