Urinary tuberculosis: a cohort of 79 adult cases

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dc.contributor.authorAltiparmak, Mehmet Riza
dc.contributor.authorTrabulus, Sinan
dc.contributor.authorBalkan, Ilker Inanc
dc.contributor.authorYalin, Serkan Feyyaz
dc.contributor.authorDenizli, Nazim
dc.contributor.authorAslan, Gonul
dc.contributor.authorDoruk, Hasan Erdal
dc.date.accessioned2024-04-24T17:20:28Z
dc.date.available2024-04-24T17:20:28Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractWe aimed to investigate the demographic, clinical, diagnostic, treatment and outcome features of patients with urinary tuberculosis (UTB). Patients with UTB admitted to seven separate centers across Turkey between 1995 and 2013 were retrospectively evaluated. The diagnosis of UTB was made by the presence of any clinical finding plus positivity of one of the following: (1) acid-fast bacilli (AFB) in urine, (2) isolation of Mycobacterium tuberculosis, (3) polymerase chain reaction (PCR) for M. tuberculosis, (4) histopathological evidence for TB. Seventy-nine patients (49.36% male, mean age 50.1 +/- 17.4 years) were included. Mean time between onset of symptoms and clinical diagnosis was 9.7 +/- 8.9 months. The most common signs and symptoms were hematuria (79.7%), sterile pyuria (67.1%), dysuria (51.9%), weakness (51.9%), fever (43%) and costovertebral tenderness (38%). Cystoscopy was performed in 59 (74.6%), bladder biopsy in 18 (22.8%), kidney biopsy in 1 (1.26%) and nephrectomy in 12 (15.2%) patients. Histopathological verification of UTB was achieved in 12 (63.1%) patients who undergone biopsy and in 100% of those undergone nephrectomy. Mycobacterium tuberculosis was isolated in the urine of 50 (63.3%) cases. Four-drug standard anti-TB treatment was the preferred regimen for 87.3% of the patients. Mean treatment duration was 10.5 +/- 2.7 months. Deterioration of renal function occurred in 15 (18.9%) patients two of whom progressed to end-stage renal disease and received hemodialysis. Only one patient died after 74-day medical treatment period. Cases with UTB may present with non-specific clinical features. All diagnostic studies including radiology, cyctoscopy and histopathology are of great importance to exclude UTB and prevent renal failure.en_US
dc.identifier.doi10.3109/0886022X.2015.1057460
dc.identifier.endpage1163en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue7en_US
dc.identifier.pmid26123266
dc.identifier.scopus2-s2.0-84941883370
dc.identifier.scopusqualityQ2
dc.identifier.startpage1157en_US
dc.identifier.urihttps://doi.org/10.3109/0886022X.2015.1057460
dc.identifier.urihttps://hdl.handle.net/11468/19071
dc.identifier.volume37en_US
dc.identifier.wosWOS:000361339400015
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCystoscopyen_US
dc.subjectEpidemiologyen_US
dc.subjectRenal Failureen_US
dc.subjectTreatmenten_US
dc.subjectUrinary Tuberculosisen_US
dc.titleUrinary tuberculosis: a cohort of 79 adult casesen_US
dc.titleUrinary tuberculosis: a cohort of 79 adult cases
dc.typeArticleen_US

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