Comprehensive phytochemical content by LC/MS/MS and anticholinergic, antiglaucoma, antiepilepsy, and antioxidant activity of apilarnil (Drone larvae)

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dc.authorid0000-0002-4090-7227en_US
dc.authorid0000-0001-5993-1668en_US
dc.contributor.authorİnci, Hakan
dc.contributor.authorİzol, Ebubekir
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.contributor.authorİlkaya, Mehmet
dc.contributor.authorBingöl, Zeynebe
dc.contributor.authorGülçin, İlhami
dc.date.accessioned2023-11-03T06:50:31Z
dc.date.available2023-11-03T06:50:31Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractApilarnil is 3–7 days old drone larvae. It is an organic bee product known to be rich in protein. In this study, the biological activities of Apilarnil were determined by its antioxidant and enzyme inhibition effects. Antioxidant activities were determined by Fe3+, Cu2+, Fe3+-TPTZ ((2,4,6-tris(2-pyridyl)-s-triazine), reducing ability and 1,1-diphenyl-2-picrylhydrazyl (DPPH⋅) scavenging assays. Also, its enzyme inhibition effects were tested against carbonic anhydrase I and II isoenzymes (hCA I, hCA II), acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. Antioxidant activity of Apilarnil was generally lower than the standard molecules in the applied methods. In DPPH⋅ radical scavenging assay, Apilarnil exhibited higher radical scavenging than some standards. Enzyme inhibition results towards hCA I (IC50: 14.2 μg/mL), hCA II: (IC50: 11.5 μg/mL), AChE (IC50: 22.1 μg/mL), BChE (IC50: 16.1 μg/mL) were calculated. In addition, the quantity of 53 different phytochemical compounds of Apilarnil was determined by a validated method by LC/MS/MS. Compounds with the highest concentrations (mg analyte/g dry extract) were determined as quinic acid (1091.045), fumaric acid (48.714), aconitic acid (47.218), kaempferol (39.946), and quercetin (27.508). As a result, it was determined that Apilarnil had effective antioxidant profile when compared to standard antioxidants.en_US
dc.identifier.citationİnci, H., İzol, E., Yılmaz, M. A., İlkaya, M., Bingöl, Z. ve Gülçin, İ. (2023). Comprehensive phytochemical content by LC/MS/MS and anticholinergic, antiglaucoma, antiepilepsy, and antioxidant activity of apilarnil (Drone larvae). Chemistry and Biodiversity, 20(10), 1-10.en_US
dc.identifier.doi10.1002/cbdv.202300654
dc.identifier.endpage10en_US
dc.identifier.issn1612-1872
dc.identifier.issue10en_US
dc.identifier.pmid37610045
dc.identifier.scopus2-s2.0-85169920836
dc.identifier.scopusqualityQ3
dc.identifier.startpage1en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1002/cbdv.202300654
dc.identifier.urihttps://hdl.handle.net/11468/13037
dc.identifier.volume20en_US
dc.identifier.wosWOS:001060866100001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYılmaz, Mustafa Abdullah
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Inc.en_US
dc.relation.ispartofChemistry and Biodiversity
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnticholinergicen_US
dc.subjectAntiglaucomaen_US
dc.subjectAntioxidanten_US
dc.subjectApilarnilen_US
dc.subjectPhytochemical compoundsen_US
dc.titleComprehensive phytochemical content by LC/MS/MS and anticholinergic, antiglaucoma, antiepilepsy, and antioxidant activity of apilarnil (Drone larvae)en_US
dc.titleComprehensive phytochemical content by LC/MS/MS and anticholinergic, antiglaucoma, antiepilepsy, and antioxidant activity of apilarnil (Drone larvae)
dc.typeArticleen_US

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