Serum neuron-specific enolase as a predictor of short-term outcome and its correlation with Glasgow Coma Scale in traumatic brain injury

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dc.contributor.authorGuzel, Aslan
dc.contributor.authorEr, Uygur
dc.contributor.authorTatli, Mehmet
dc.contributor.authorAluclu, Ufuk
dc.contributor.authorOzkan, Umit
dc.contributor.authorDuzenli, Yucel
dc.contributor.authorSatici, Omer
dc.date.accessioned2024-04-24T16:02:03Z
dc.date.available2024-04-24T16:02:03Z
dc.date.issued2008
dc.departmentDicle Üniversitesien_US
dc.description.abstractElevated serum neuron-specific enolase levels are correlated with brain cell damage. Low scores according to Glasgow Coma Scale are also considered as serious poor prognostic factor. The aims of the study were to investigate whether there is a correlation between the two measurements in patients with traumatic brain injury and whether serum neuron-specific enolase levels have potential as a screening test to predict outcome. A total of 169 consecutive patients with traumatic brain injury admitted to our clinic between 2002 and 2005 are included in this study. Those patients, who had any major health problem before trauma, were excluded from the study. However, patients with isolated head injury were included in the study. Serial serum neuron-specific enolase concentrations taken at the first 2, 24, and 48 h after traumatic brain injury were analyzed. A computed tomography was performed on each patient on admission. Their Glasgow Coma Scale scores were recorded serially. The relationship between Glasgow Coma Scale scores and the serum neuron-specific enolase levels were assessed by statistical methods. There was a significant negative correlation between the serum neuron-specific enolase levels and Glasgow Coma Scale scores. The levels of neuron-specific enolase were significantly higher in the patients who died in 30 days after trauma and whose scores were lower than or equal to 8 points in Glasgow Coma Scale. Although there are several serious limitations of the use of neuron-specific enolase as a biomarker in traumatic brain injury (i.e., hypoperfusion, extracranial trauma, bleeding, liver, or kidney damage also increase the level of neuron-specific enolase), its concentrations may be useful as a practical and helpful screening test to identify neurotrauma patients who are at increased risk and may provide supplementary estimation with radiological and clinical findings.en_US
dc.identifier.doi10.1007/s10143-008-0148-2
dc.identifier.endpage444en_US
dc.identifier.issn0344-5607
dc.identifier.issn1437-2320
dc.identifier.issue4en_US
dc.identifier.pmid18560914
dc.identifier.scopus2-s2.0-51349097706
dc.identifier.scopusqualityQ1
dc.identifier.startpage439en_US
dc.identifier.urihttps://doi.org/10.1007/s10143-008-0148-2
dc.identifier.urihttps://hdl.handle.net/11468/14592
dc.identifier.volume31en_US
dc.identifier.wosWOS:000258962500017
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofNeurosurgical Review
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeuron-Specific Enolaseen_US
dc.subjectGlasgow Coma Scaleen_US
dc.subjectOutcomeen_US
dc.subjectPrognosisen_US
dc.subjectTraumatic Brain Injuryen_US
dc.titleSerum neuron-specific enolase as a predictor of short-term outcome and its correlation with Glasgow Coma Scale in traumatic brain injuryen_US
dc.titleSerum neuron-specific enolase as a predictor of short-term outcome and its correlation with Glasgow Coma Scale in traumatic brain injury
dc.typeArticleen_US

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