Colistin use in critically ill neonates: A case–control study
Yükleniyor...
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier (Singapore) Pte Ltd
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background The aim of this study was to assess the safety and efficacy of colistin use in critically ill neonates. Methods This was a case–control study that included newborn infants with proven or suspected nosocomial infections between January 2012 and October 2015, at two centers in Diyarbakir, Turkey. The clinical and laboratory characteristics and outcomes of patients who received colistin therapy were reviewed and compared to patients who were treated with antimicrobial agents other than colistin during the same period. Results Forty-seven cases who received intravenous colistin (colistin group) and 59 control patients (control group) were included. There were no significant differences between the groups regarding outcomes and nephrotoxicity, including acute renal failure. Colistin therapy was associated with significantly reduced serum magnesium (1.38 ± 0.39 mg/dL vs. 1.96 ± 0.39 mg/dL, p < 0.001) and hypokalemia (46.8% vs. 25.4%, p = 0.026). The patients who received colistin also had longer hospital stays (43 (32–70) days vs. 39 (28–55) days, p = 0.047), a higher rate of previous carbapenem exposure (40.4% vs. 11.9%, p = 0.001), and a higher age at the onset of infection (13 (10–21) days vs. 11 (9–15) days, p = 0.03). Conclusion This study showed that colistin was both effective and safe for treating neonatal infections caused by multidrug-resistant gram-negative bacteria. However, intravenous colistin use was significantly associated with hypomagnesemia and hypokalemia.
Açıklama
Anahtar Kelimeler
Colistin, Gram-negative bacteria, Nosocomial infection, Multi-drug resistant, Neonate
Kaynak
Pediatrics and Neonatology
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
58
Sayı
6
Künye
İpek, M. Ş., Aktar, F., Okur, N., Çelik, M. ve Özbek, E. (2017). Colistin use in critically ill neonates: A case–control study. Pediatrics and Neonatology, 58(6), 490-496.
