Colistin use in critically ill neonates: A case–control study

Yükleniyor...
Küçük Resim

Tarih

2017

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Elsevier (Singapore) Pte Ltd

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Background The aim of this study was to assess the safety and efficacy of colistin use in critically ill neonates. Methods This was a case–control study that included newborn infants with proven or suspected nosocomial infections between January 2012 and October 2015, at two centers in Diyarbakir, Turkey. The clinical and laboratory characteristics and outcomes of patients who received colistin therapy were reviewed and compared to patients who were treated with antimicrobial agents other than colistin during the same period. Results Forty-seven cases who received intravenous colistin (colistin group) and 59 control patients (control group) were included. There were no significant differences between the groups regarding outcomes and nephrotoxicity, including acute renal failure. Colistin therapy was associated with significantly reduced serum magnesium (1.38 ± 0.39 mg/dL vs. 1.96 ± 0.39 mg/dL, p < 0.001) and hypokalemia (46.8% vs. 25.4%, p = 0.026). The patients who received colistin also had longer hospital stays (43 (32–70) days vs. 39 (28–55) days, p = 0.047), a higher rate of previous carbapenem exposure (40.4% vs. 11.9%, p = 0.001), and a higher age at the onset of infection (13 (10–21) days vs. 11 (9–15) days, p = 0.03). Conclusion This study showed that colistin was both effective and safe for treating neonatal infections caused by multidrug-resistant gram-negative bacteria. However, intravenous colistin use was significantly associated with hypomagnesemia and hypokalemia.

Açıklama

Anahtar Kelimeler

Colistin, Gram-negative bacteria, Nosocomial infection, Multi-drug resistant, Neonate

Kaynak

Pediatrics and Neonatology

WoS Q Değeri

Q3

Scopus Q Değeri

Q2

Cilt

58

Sayı

6

Künye

İpek, M. Ş., Aktar, F., Okur, N., Çelik, M. ve Özbek, E. (2017). Colistin use in critically ill neonates: A case–control study. Pediatrics and Neonatology, 58(6), 490-496.