Synaptosomal-Associated Protein 25 Gene Polymorphisms and Antisocial Personality Disorder: Association With Temperament and Psychopathy

Basit Öğe Kaydı
dc.contributor.authorBasoglu, Cengiz
dc.contributor.authorOner, Ozgur
dc.contributor.authorAtes, Alpay
dc.contributor.authorAlgul, Ayhan
dc.contributor.authorBez, Yasin
dc.contributor.authorCetin, Mesut
dc.contributor.authorHerken, Hasan
dc.date.accessioned2024-04-24T17:14:35Z
dc.date.available2024-04-24T17:14:35Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: The molecular genetic of personality disorders has been investigated in several studies; however, the association of antisocial behaviours with synaptosomal-associated protein 25 (SNAP25) gene polymorphisms has not. This association is of interest as SNAP25 gene polymorphism has been associated with attention-deficit hyperactivity disorder and personality. Methods: We compared the distribution of DdeI and MnlI polymorphisms in 91 young male offenders and in 38 sex-matched healthy control subjects. We also investigated the association of SNAP25 gene polymorphisms with severity of psychopathy and with temperament traits: novelty seeking, harm avoidance, and reward dependence. Results: The MnlI TIT and DdeI TIT genotypes were more frequently present in male subjects with antisocial personality disorder (APD) than in sex-matched healthy control subjects. The association was stronger when the frequency of both DdeI and MnlI TIT were taken into account. In the APD group, the genotype was not significantly associated with the Psychopathy Checklist Revised scores, measuring the severity of psychopathy. However, the APD subjects with the MnlI T/T genotype had higher novelty seeking scores; whereas, subjects with the DdeI T/T genotype had lower reward dependence scores. Again, the association between genotype and novelty seeking was stronger when both DdeI and MnlI genotypes were taken into account. Conclusion: DdeI and MnlI TIT genotypes may be a risk factor for antisocial behaviours. The association of the SNAP25 DdeI TIT and MnlI T/T genotypes with lower reward dependence and higher novelty seeking suggested that SNAP25 genotype might influence other personality disorders, as well.en_US
dc.description.sponsorshipTurkish Association for Psychopharmacology; Fogarty/NIH at Children's Hospital Boston [TW05807]en_US
dc.description.sponsorshipWriting of this work was partially supported by the Turkish Association for Psychopharmacology and Fogarty/NIH D43 Grant TW05807 at Children's Hospital Boston.en_US
dc.identifier.doi10.1177/070674371105600605
dc.identifier.endpage347en_US
dc.identifier.issn0706-7437
dc.identifier.issn1497-0015
dc.identifier.issue6en_US
dc.identifier.pmid21756448
dc.identifier.scopus2-s2.0-79960441556
dc.identifier.scopusqualityQ1
dc.identifier.startpage341en_US
dc.identifier.urihttps://doi.org/10.1177/070674371105600605
dc.identifier.urihttps://hdl.handle.net/11468/18071
dc.identifier.volume56en_US
dc.identifier.wosWOS:000291765700005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofCanadian Journal of Psychiatry-Revue Canadienne De Psychiatrie
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntisocial Personality Disorderen_US
dc.subjectGene Polymorphismen_US
dc.subjectSynaptosomal-Associated Protein 25 Geneen_US
dc.subjectTemperamenten_US
dc.subjectPsychopathyen_US
dc.subjectPersonality Disorderen_US
dc.titleSynaptosomal-Associated Protein 25 Gene Polymorphisms and Antisocial Personality Disorder: Association With Temperament and Psychopathyen_US
dc.titleSynaptosomal-Associated Protein 25 Gene Polymorphisms and Antisocial Personality Disorder: Association With Temperament and Psychopathy
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu