Anti-HDV IgM as a marker of disease activity in hepatitis delta

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dc.authorid0000-0001-6103-5336en_US
dc.authorid0000-0003-2137-7934en_US
dc.contributor.authorWranke, Anika
dc.contributor.authorHeidrich, Benjamin
dc.contributor.authorErnst, Stefanie
dc.contributor.authorSerrano, Beatriz Calle
dc.contributor.authorCaruntu, Florin Alexandru
dc.contributor.authorCurescu, Manuela Gabriela
dc.contributor.authorYalçın, Kendal
dc.date.accessioned2024-04-05T11:35:29Z
dc.date.available2024-04-05T11:35:29Z
dc.date.issued2014en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalıen_US
dc.description.abstractBackground: Hepatitis delta frequently leads to liver cirrhosis and hepatic decompensation. As treatment options are limited, there is a need for biomarkers to determine disease activity and to predict the risk of disease progression. We hypothesized that anti-HDV IgM could represent such a marker. Methods: Samples of 120 HDV-infected patients recruited in an international multicenter treatment trial (HIDIT-2) were studied. Anti-HDV IgM testing was performed using ETI-DELTA-IGMK-2-assay (DiaSorin). In addition, fifty cytokines, chemokines and angiogenetic factors were measured using multiplex technology (Bio-Plex System). A second independent cohort of 78 patients was studied for the development of liver-related clinical endpoints (decompensation, HCC, liver transplantation or death; median follow up of 3.0 years, range 0.6–12). Results: Anti-HDV IgM serum levels were negative in 18 (15%), low (OD,0.5) in 76 (63%), and high in 26 (22%) patients of the HIDIT-2 cohort. Anti-HDV IgM were significantly associated with histological inflammatory (p,0.01) and biochemical disease activity (ALT, AST p,0.01). HDV replication was independent from anti-HDV IgM, however, low HBV-DNA levels were observed in groups with higher anti-HDV IgM levels (p,0.01). While high IP-10 (CXCL10) levels were seen in greater groups of anti-HDV IgM levels, various other antiviral cytokines were negatively associated with anti-HDV IgM. Associations between anti-HDV IgM and ALT, AST, HBV-DNA were confirmed in the independent cohort. Clinical endpoints occurred in 26 anti-HDV IgM positive patients (39%) but in only one anti-HDV IgM negative individual (9%; p = 0.05). Conclusions: Serum anti-HDV IgM is a robust, easy-to-apply and relatively cheap marker to determine disease activity in hepatitis delta which has prognostic implications. High anti-HDV IgM levels may indicate an activated interferon system but exhausted antiviral immunity.en_US
dc.identifier.citationWranke, A., Heidrich, B., Ernst, S., Serrano, B. C., Caruntu, F. A., Curescu, M. G. ve diğerleri. (2014). Anti-HDV IgM as a marker of disease activity in hepatitis delta. Public Library of Science, 9(7), 1-13.en_US
dc.identifier.doi10.1371/journal.pone.0101002
dc.identifier.endpage13en_US
dc.identifier.issn1932-6203
dc.identifier.issue7en_US
dc.identifier.pmid25072849
dc.identifier.scopus2-s2.0-84904991642
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0101002
dc.identifier.urihttps://hdl.handle.net/11468/13855
dc.identifier.volume9en_US
dc.identifier.wosWOS:000341307600005
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYalçın, Kendal
dc.language.isoenen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.ispartofPLoS ONE
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnti-HDVen_US
dc.subjectHepatitis deltaen_US
dc.titleAnti-HDV IgM as a marker of disease activity in hepatitis deltaen_US
dc.titleAnti-HDV IgM as a marker of disease activity in hepatitis delta
dc.typeArticleen_US

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