N-terminal pro-brain natriuretic peptide in newly diagnosed acromegaly

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dc.contributor.authorArikan, S.
dc.contributor.authorBahceci, M.
dc.contributor.authorTuzcu, A.
dc.contributor.authorGokalp, D.
dc.date.accessioned2024-04-24T15:59:41Z
dc.date.available2024-04-24T15:59:41Z
dc.date.issued2010
dc.departmentDicle Üniversitesien_US
dc.description.abstractIntroduction and aim: The mechanisms of acromegalic cardiomyopathy are not clearly understood. Brain natriuretic peptide (BNP) and N-terminal fragment of its pro-hormone (NT-proBNP) are released by the cardiac ventricles and increase in heart failure. In the present study, we aimed to evaluate serum NT-proBNP levels in acromegalic patients and determine a relationship between NT-proBNP levels and echocardiographic parameters. Subjects and methods: Twenty-two newly diagnosed acromegalic patients [mean age 38.85 +/- 11.06 yr; body mass index (BMI): 28.51 +/- 3.48 kg/m(2)] and 26 age- and BMI-matched healthy control subjects (mean age 32.9 +/- 12.6 yr; BMI: 26.2 +/- 5.3 kg/m2) were included in the study. Standard oral glucose tolerance test (OGTT) was performed. Serum NT-proBNP and GH were measured at the beginning of the OGTT (0 min). Body fat analyses were measured by bioelectrical impedance. Echocardiography was used in cardiac evaluations. Results: The mean NT-proBNP level in the acromegalic group was not significantly different from the control subjects (55.89 +/- 46.64 pg/ml in acromegaly vs 28.76 +/- 22.13 pg/ml in control subjects). There were no correlations between the serum NT-proBNP, GH, and IGF-I levels. Echocardiography revealed significantly increased left ventricular end-diastolic diameter (p=0.008), interventricular septum thickness (p=0.009), left atrium (p=0.029), and right ventricle diameter (p=0.027) in the acromegalic group. Conclusion: NT-proBNP levels were found to be slightly higher in acromegalic patients as an indicator of heart failure, but the increase was not statistically significant. Although these cardiac structural changes in newly diagnosed acromegalic patients are present, the normal level of NT-proBNP shows that NT-proBNP may not be a good indicator in acromegaly. (J. Endocrinol. Invest. 33: 571-575, 2010) (C) 2010, Editrice Kurtisen_US
dc.identifier.doi10.1007/BF03346650
dc.identifier.endpage575en_US
dc.identifier.issn0391-4097
dc.identifier.issue8en_US
dc.identifier.pmid20930495
dc.identifier.scopus2-s2.0-78049400341
dc.identifier.scopusqualityQ1
dc.identifier.startpage571en_US
dc.identifier.urihttps://doi.org/10.1007/BF03346650
dc.identifier.urihttps://hdl.handle.net/11468/14209
dc.identifier.volume33en_US
dc.identifier.wosWOS:000283521400012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherEditrice Kurtis S R Len_US
dc.relation.ispartofJournal of Endocrinological Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcromegalyen_US
dc.subjectGrowth Hormoneen_US
dc.subjectNt-Probnpen_US
dc.titleN-terminal pro-brain natriuretic peptide in newly diagnosed acromegalyen_US
dc.titleN-terminal pro-brain natriuretic peptide in newly diagnosed acromegaly
dc.typeArticleen_US

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