Effect of cadmium chloride toxicity on olfactory mucosa

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dc.authorid0000-0003-1573-283Xen_US
dc.authorid0000-0002-2353-1184en_US
dc.contributor.authorHaznedar, Berzan
dc.contributor.authorGök, Ertuğrul
dc.contributor.authorDeveci, Engin
dc.date.accessioned2023-09-27T07:05:02Z
dc.date.available2023-09-27T07:05:02Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Adli Tıp Ana Bilim Dalıen_US
dc.description.abstractCadmium is a highly toxic metal and affects the respiratory mucosa. The aim of the study is to show the inflammation and degenerative effect of cadmium on the olfactory mucosa. In this study, eight-week-old Wistar rats with an average weight of 170-190 g were divided into two groups (control and experiment) with 20 animals in each group and used in the experiments.The rats in the experimental group were given 2 mg/kg/day powdered cadmium chloride dissolved in water intraperitoneally every day for two weeks. At the end of the experiment, the nasal cavity was completely removed with anesthesia. Concha nasalis superior was separated, fixed with zinc-Formalin solution and decalcified with 5 % EDTA (Ethylene-diaminetetraacetic acid).After routine histopathological procedure, APAF-1 antibody was used for expression of Hematoxylin-Eosin (HE) and immunohistochemistry. Histopathological examination revealed interruptions in the basement membrane structure due to cadmium and degenerative changes in stem cells, degeneration in sensory cells and pycnosis in nuclei, dilatation in blood vessels and increased inflammation in connective tissue. APAF-1 expression was found to increase in epithelial cells and olfactory glands (Bowman gland) cells. It has been thought that cadmium toxicity increases cell degeneration and inflammation in the olfactory mucosa and may significantly affect cell death and olfactory metabolism by inducing the pro-apoptotic process.en_US
dc.identifier.citationHaznedar, B., Gök, E. ve Deveci, E. (2022). Effect of cadmium chloride toxicity on olfactory mucosa. International Journal of Morphology, 40(6), 1574-1578.en_US
dc.identifier.doi10.4067/S0717-95022022000601574
dc.identifier.endpage1578en_US
dc.identifier.issn0717-9367
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85147368284
dc.identifier.scopusqualityQ3
dc.identifier.startpage1574en_US
dc.identifier.urihttps://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022022000601574
dc.identifier.urihttps://hdl.handle.net/11468/12614
dc.identifier.volume40en_US
dc.identifier.wosWOS:000918579700024
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorGök, Ertuğrul
dc.institutionauthorDeveci, Engin
dc.language.isoenen_US
dc.publisherUniversidad de la Fronteraen_US
dc.relation.ispartofInternational Journal of Morphology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAPAF-1 (Apoptotic Protease Activating Factor-1)en_US
dc.subjectCadmium chlorideen_US
dc.subjectHistopathologyen_US
dc.subjectOlfactory mucosaeen_US
dc.subjectRaten_US
dc.titleEffect of cadmium chloride toxicity on olfactory mucosaen_US
dc.titleEffect of cadmium chloride toxicity on olfactory mucosa
dc.typeArticleen_US

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