Effect of cadmium chloride toxicity on olfactory mucosa

Yükleniyor...
Küçük Resim

Tarih

2022

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Universidad de la Frontera

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Cadmium is a highly toxic metal and affects the respiratory mucosa. The aim of the study is to show the inflammation and degenerative effect of cadmium on the olfactory mucosa. In this study, eight-week-old Wistar rats with an average weight of 170-190 g were divided into two groups (control and experiment) with 20 animals in each group and used in the experiments.The rats in the experimental group were given 2 mg/kg/day powdered cadmium chloride dissolved in water intraperitoneally every day for two weeks. At the end of the experiment, the nasal cavity was completely removed with anesthesia. Concha nasalis superior was separated, fixed with zinc-Formalin solution and decalcified with 5 % EDTA (Ethylene-diaminetetraacetic acid).After routine histopathological procedure, APAF-1 antibody was used for expression of Hematoxylin-Eosin (HE) and immunohistochemistry. Histopathological examination revealed interruptions in the basement membrane structure due to cadmium and degenerative changes in stem cells, degeneration in sensory cells and pycnosis in nuclei, dilatation in blood vessels and increased inflammation in connective tissue. APAF-1 expression was found to increase in epithelial cells and olfactory glands (Bowman gland) cells. It has been thought that cadmium toxicity increases cell degeneration and inflammation in the olfactory mucosa and may significantly affect cell death and olfactory metabolism by inducing the pro-apoptotic process.

Açıklama

Anahtar Kelimeler

APAF-1 (Apoptotic Protease Activating Factor-1), Cadmium chloride, Histopathology, Olfactory mucosae, Rat

Kaynak

International Journal of Morphology

WoS Q Değeri

Q4

Scopus Q Değeri

Q3

Cilt

40

Sayı

6

Künye

Haznedar, B., Gök, E. ve Deveci, E. (2022). Effect of cadmium chloride toxicity on olfactory mucosa. International Journal of Morphology, 40(6), 1574-1578.