Effect of cadmium chloride toxicity on olfactory mucosa
Yükleniyor...
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Universidad de la Frontera
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Cadmium is a highly toxic metal and affects the respiratory mucosa. The aim of the study is to show the inflammation and
degenerative effect of cadmium on the olfactory mucosa. In this study, eight-week-old Wistar rats with an average weight of 170-190 g were
divided into two groups (control and experiment) with 20 animals in each group and used in the experiments.The rats in the experimental group
were given 2 mg/kg/day powdered cadmium chloride dissolved in water intraperitoneally every day for two weeks. At the end of the experiment,
the nasal cavity was completely removed with anesthesia. Concha nasalis superior was separated, fixed with zinc-Formalin solution and decalcified
with 5 % EDTA (Ethylene-diaminetetraacetic acid).After routine histopathological procedure, APAF-1 antibody was used for expression of
Hematoxylin-Eosin (HE) and immunohistochemistry. Histopathological examination revealed interruptions in the basement membrane structure
due to cadmium and degenerative changes in stem cells, degeneration in sensory cells and pycnosis in nuclei, dilatation in blood vessels and
increased inflammation in connective tissue. APAF-1 expression was found to increase in epithelial cells and olfactory glands (Bowman gland)
cells. It has been thought that cadmium toxicity increases cell degeneration and inflammation in the olfactory mucosa and may significantly affect
cell death and olfactory metabolism by inducing the pro-apoptotic process.
Açıklama
Anahtar Kelimeler
APAF-1 (Apoptotic Protease Activating Factor-1), Cadmium chloride, Histopathology, Olfactory mucosae, Rat
Kaynak
International Journal of Morphology
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
40
Sayı
6
Künye
Haznedar, B., Gök, E. ve Deveci, E. (2022). Effect of cadmium chloride toxicity on olfactory mucosa. International Journal of Morphology, 40(6), 1574-1578.
