The effect of L-arginine methyl ester on indices of free radical involvement in a rat model of experimental nephrocalcinosis

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dc.contributor.authorOzturk, Hayrettin
dc.contributor.authorOzturk, Hulya
dc.contributor.authorYagmur, Yusuf
dc.contributor.authorBuyukbayram, Huseyin
dc.date.accessioned2024-04-24T15:59:50Z
dc.date.available2024-04-24T15:59:50Z
dc.date.issued2006
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this study was to test the effect of L-arginine methyl ester (L-Arg) on indices of free radical involvement in a rat model of experimental nephrocalcinosis. Twenty-eight Sprague-Dawley rats were randomized into four groups of seven. The first group (Gl), the sham-control group received pure distilled drinking water. The second group (G2) received drinking water containing 0.7% ethylene glycol (EG) in distilled water for 3 weeks. The third group (G3) received drinking water containing 0.7% EG in distilled water for 3 weeks and L-Arg was administered for 3 weeks. The fourth group (G4) received drinking water containing 0.7% EG in distilled water for 3 weeks and L-NAME was administered for 3 weeks. Urine and aortic blood was collected to determine some parameters. The kidneys were also removed for histological examination. The increase in blood urea nitrogen, serum creatinine, K(+), Mg(2+) and uric acid were mild in group 3 compared with the groups 2 and 4. The urinary concentrations of Na(+), K(+), Mg(2+) and uric acid were noticed to be similar among the groups. However, Ca(2+) and oxalate excretion were significantly higher in groups 2, 3 and 4 than in group 1. The mean values of SOD, CAT and GSH-Px values were significantly increased in group 3 when compared to groups 2 and 4. Presence of aggregated urinary crystals was clearer in experimental groups compared to group 1. The tubular dilatation, epithelial degeneration and lymphocytic infiltration were significantly found in groups 2 and 4. Mild tissue damage was observed in L-Arg-pretreated rats. Under polarized light microscope intense crystals in the cortex and medulla were observed in the kidney of group 2 and 4 and moderate crystals were noticed in group 3. In conclusion, L-Arg supplementation may decrease free radicals and tubulary membrane injury in nephrocalcinosis due to infiltrating leukocytes and decreased antioxidant enzyme activities in rats fed with EG diet.en_US
dc.identifier.doi10.1007/s00240-006-0061-5
dc.identifier.endpage314en_US
dc.identifier.issn0300-5623
dc.identifier.issue5en_US
dc.identifier.pmid16823549
dc.identifier.scopus2-s2.0-33749023565
dc.identifier.scopusqualityN/A
dc.identifier.startpage305en_US
dc.identifier.urihttps://doi.org/10.1007/s00240-006-0061-5
dc.identifier.urihttps://hdl.handle.net/11468/14279
dc.identifier.volume34en_US
dc.identifier.wosWOS:000241703200003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofUrological Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectExperimental Nephrocalcinosisen_US
dc.subjectRaten_US
dc.subjectCalcium Oxalateen_US
dc.subjectL-Arginine Methyl Esteren_US
dc.subjectNg-Nitro-L-Arginine-Methyl Esteren_US
dc.titleThe effect of L-arginine methyl ester on indices of free radical involvement in a rat model of experimental nephrocalcinosisen_US
dc.titleThe effect of L-arginine methyl ester on indices of free radical involvement in a rat model of experimental nephrocalcinosis
dc.typeArticleen_US

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