Histopathologic Diagnosis of Thyroid Tuberculosis

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dc.contributor.authorOzekinci, Selver
dc.contributor.authorMizrak, Buelent
dc.contributor.authorSaruhan, Guelbin
dc.contributor.authorSenturk, Senem
dc.date.accessioned2024-04-24T17:08:03Z
dc.date.available2024-04-24T17:08:03Z
dc.date.issued2009
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Thyroid tuberculosis is rarely encountered. Due to the absence of specific signs and symptoms, the diagnosis is difficult without histopathologic examination of surgical material. In this study, we aim to present histopathologic findings of our patients with thyroid tuberculosis. Methods: We retrospectively reviewed 800 thyroidectomy specimens from the pathology laboratories of two medical centers that were obtained over a 5-year period. We reviewed clinical and laboratory data, fine-needle aspiration cytology smears, and 4-mu m formalin-fixed paraffin-embedded hematoxylin-eosin sections and Erlich Ziehl Nelsen-stained sections of granulomatous thyroiditis. Results: We found nine cases of granulomatous thyroiditis and detected five cases of thyroid tuberculosis. Thyroid ultrasound revealed hypoechoic nodules ranging between 1.3 and 2.5 cm in all patients with thyroid tuberculosis. Fine-needle aspiration cytology smears, which showed thyrocytes, macrophages, and lymphocytes with a colloid background, were nonspecific. Microscopic examination of all thyroids revealed granulomas of different sizes, which were composed of Langhans' giant cells, epithelioid histiocytes, and lymphocytes around caseation necrosis. In Erlich Ziehl Nelsen-stained sections of three cases, bacilli were seen. Bacilli were identified in the microbiology culture of the remaining two patients. Conclusions: Thyroid tuberculosis is diagnosed by histopathologic examinations and microbiologic cultures. When granulomatous thyroiditis is encountered, tuberculosis should be kept in mind and Erlich Ziehl Nelsen staining should be performed for prompt diagnosis.en_US
dc.identifier.doi10.1089/thy.2009.0189
dc.identifier.endpage986en_US
dc.identifier.issn1050-7256
dc.identifier.issn1557-9077
dc.identifier.issue9en_US
dc.identifier.pmid19678750
dc.identifier.scopus2-s2.0-70349123074
dc.identifier.scopusqualityQ1
dc.identifier.startpage983en_US
dc.identifier.urihttps://doi.org/10.1089/thy.2009.0189
dc.identifier.urihttps://hdl.handle.net/11468/17176
dc.identifier.volume19en_US
dc.identifier.wosWOS:000269577900010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofThyroid
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleHistopathologic Diagnosis of Thyroid Tuberculosisen_US
dc.titleHistopathologic Diagnosis of Thyroid Tuberculosis
dc.typeArticleen_US

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