EFFECTS OF TYLOSIN ON SERUM CYTOKINE LEVELS IN HEALTHY AND LIPOPOLYSACCHARIDE-TREATED MICE

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dc.contributor.authorEr, Ayse
dc.contributor.authorYazar, Enver
dc.contributor.authorUney, Kamil
dc.contributor.authorElmas, Muammer
dc.contributor.authorAltan, Feray
dc.contributor.authorCetin, Gul
dc.date.accessioned2024-04-24T17:18:05Z
dc.date.available2024-04-24T17:18:05Z
dc.date.issued2010
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe effects of different doses of tylosin on serum cytokine concentrations were investigated in healthy and lipopolysaccharide-treated mice. The mice were divided into seven groups. Lipopolysaccharide (LPS) was injected into the positive control group. The other six groups received three different tylosin doses concurrently without or with LPS: 10 mg/kg, 100 mg/kg, 500 mg/kg, 10 mg/kg + LPS, 100 mg/kg + LPS and 500 mg/kg + LPS. After treatment, serum samples were collected at 0, 1, 2, 3, 6, 12 and 24 hours. Serum tumour necrosis factor alpha (TNF alpha), interleukin 1 beta (IL1 beta) and IL10 levels were determined by enzyme-linked immunosorbent assay (ELISA). Tylosin doses of 10 and 100 mg/kg induced no cytokine production in the healthy mice. Tylosin at 500 mg/kg had no effect on TNF alpha or IL1 beta production, but it induced IL10 production in healthy mice. All doses of tylosin reduced the elevated TNF alpha and IL1 beta in LPS-treated mice but increased their IL10 levels. In conclusion, these data suggest that tylosin has an immunomodulatory effect at the dose recommended for use against infection.en_US
dc.description.sponsorshipSUBAK [08401070]en_US
dc.description.sponsorshipThis study was supported by SUBAK (08401070).en_US
dc.identifier.doi10.1556/AVet.58.2010.1.8
dc.identifier.endpage81en_US
dc.identifier.issn0236-6290
dc.identifier.issn1588-2705
dc.identifier.issue1en_US
dc.identifier.pmid20159741
dc.identifier.scopus2-s2.0-77249179775
dc.identifier.scopusqualityQ2
dc.identifier.startpage75en_US
dc.identifier.urihttps://doi.org/10.1556/AVet.58.2010.1.8
dc.identifier.urihttps://hdl.handle.net/11468/18593
dc.identifier.volume58en_US
dc.identifier.wosWOS:000274582400008
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherAkademiai Kiado Zrten_US
dc.relation.ispartofActa Veterinaria Hungarica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTylosinen_US
dc.subjectLpsen_US
dc.subjectTnf Alphaen_US
dc.subjectIl1 Betaen_US
dc.subjectIl10en_US
dc.titleEFFECTS OF TYLOSIN ON SERUM CYTOKINE LEVELS IN HEALTHY AND LIPOPOLYSACCHARIDE-TREATED MICEen_US
dc.titleEFFECTS OF TYLOSIN ON SERUM CYTOKINE LEVELS IN HEALTHY AND LIPOPOLYSACCHARIDE-TREATED MICE
dc.typeArticleen_US

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