Evaluation of ocular hypoperfusion in patients with acromegaly by using optical coherence tomography angiography

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dc.authorid0000-0002-3591-721Xen_US
dc.authorid0000-0001-5742-1293en_US
dc.authorid0000-0001-8856-0528en_US
dc.authorid0000-0002-5323-2257en_US
dc.authorid0000-0003-2348-4856en_US
dc.contributor.authorKarahan, Mine
dc.contributor.authorDemirtaş, Atılım Armağan
dc.contributor.authorErdem, Seyfettin
dc.contributor.authorAva, Sedat
dc.contributor.authorPekkolay, Zafer
dc.contributor.authorKeklikçi, Uğur
dc.date.accessioned2022-06-02T06:43:49Z
dc.date.available2022-06-02T06:43:49Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalıen_US
dc.descriptionWOS:000609589900001
dc.descriptionPMID: 33445974
dc.description.abstractPurpose: This study aimed to evaluate the retinal blood vessel parameters and the foveal avascular zone (FAZ) area using optical coherence tomography angiography (OCTA) in patients with acromegaly in comparison with healthy controls. Methods: A total of 45 patients with acromegaly and 45 healthy controls were included in this study. In all patients, the vessel density (VD) of the deep and superficial macular vascular networks and the foveal avascular zone (FAZ) were measured using OCTA. The correlation of insulin-like growth factor 1 (IGF-1) level and disease duration with deep macular VD and FAZ values was analyzed. All parameters were registered. Results were assessed and compared between the two groups. Results: Deep macular plexus VD values were lower in patients with acromegaly compared to the control group. No significant differences in VD values in the superficial segment, except for that in the inferior parafovea (P = .01) were found between the two groups. Furthermore, patients with acromegaly showed enlargement in the superficial (P = .30) and deep FAZ areas (P < .001). IGF-1 level and disease duration showed a significant negative correlation with the deep whole image (R = -0.216, P = .041, R = -0.339, P = .001, respectively), deep parafovea (R = -0.271, P = .01; R = -0.372, P < .001, respectively), deep parafovea superior hemi (R = -0.342, P = .001; R = -0.350, P = .001, respectively), deep parafovea temporal (R = -0.224, P = .034; R = -0.234, P = .026, respectively), deep parafovea nasal (R = -0.320, P = .002; R = -0.361, P < .001, respectively), and deep parafovea superior VD values (R = -0.293, P = .005; R = -0.307, P = .003, respectively) and a significant positive correlation with the deep FAZ area values (R = 0.244, P = .02; R = 0.329, P = .002, respectively). Conclusion: VD values in the deep macular capillary plexus were lower in patients with acromegaly, and the superficial and deep FAZ area enlarged. Patients with acromegaly may have an increased risk of developing ocular vascular complications. OCTA can be used to evaluate retinal blood VD in patients with acromegaly.en_US
dc.identifier.citationKarahan, M., Demirtaş, A.A., Erdem, S., Ava, S., Pekkolay, Z. ve Keklikçi, U. (2021). Evaluation of ocular hypoperfusion in patients with acromegaly by using optical coherence tomography angiography. Current Eye Reserach, 46(8), 1209-1213.en_US
dc.identifier.doi10.1080/02713683.2021.1877311
dc.identifier.endpage1213en_US
dc.identifier.issn0271-3683
dc.identifier.issn1460-2202
dc.identifier.issue8en_US
dc.identifier.pmid33445974
dc.identifier.scopus2-s2.0-85099948249
dc.identifier.scopusqualityQ1
dc.identifier.startpage1209en_US
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/02713683.2021.1877311
dc.identifier.urihttps://hdl.handle.net/11468/9950
dc.identifier.volume46en_US
dc.identifier.wosWOS:000609589900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKarahan, Mine
dc.institutionauthorErdem, Seyfettin
dc.institutionauthorAva, Sedat
dc.institutionauthorPekkolay, Zafer
dc.institutionauthorKeklikçi, Uğur
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.relation.ispartofCurrent Eye Reserach
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcromegalyen_US
dc.subjectOptical coherence tomography angiographyen_US
dc.subjectVessel densityen_US
dc.subjectFoveal avascular zoneen_US
dc.subjectOcular hypoperfusionen_US
dc.titleEvaluation of ocular hypoperfusion in patients with acromegaly by using optical coherence tomography angiographyen_US
dc.titleEvaluation of ocular hypoperfusion in patients with acromegaly by using optical coherence tomography angiography
dc.typeArticleen_US

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