Serum levels of IL-1 beta, sIL-2R, IL-6, IL-8, and TNF-alpha in febrile children with cancer and neutropenia

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dc.authorid0000-0002-5299-9480en_US
dc.authorid0000-0001-8463-2723en_US
dc.contributor.authorSöker, Murat
dc.contributor.authorÇolpan, Leyla
dc.contributor.authorEce, Aydın
dc.contributor.authorDevecioğlu, Celal
dc.contributor.authorHaspolat, Yusuf Kenan
dc.date.accessioned2021-12-08T13:11:13Z
dc.date.available2021-12-08T13:11:13Z
dc.date.issued2001en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractSerum levels of interleukin-1 beta (IL-1beta), soluble interleukin 2 receptors (sIL-2R), interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-alpha (TNF-alpha) were measured to predict some characteristics of febrile episodes in children with cancer and neutropenia. Forty-eight episodes of febrile neutropenia were determined in 23 pediatric cancer patients, including 35 febrile episodes without identifiable source, 7 episodes of bacteremia due to Gram-negative organisms and 4 due to Gram-positive organisms, and 2 fungal infections. Interleukin-6, sIL-2R, and IL-8 levels were significantly higher at the beginning of the febrile episodes than those of controls (p < 0.001, p < 0.001, and p < 0.001). Interleukin-6, slL-2R, and IL-8 levels were higher in patients with bacteremia due to Gram-negative organisms than in those with Gram-positive ones (p = 0.042, p = 0.006, and p = 0.023, respectively). TNF-alpha and IL-1beta levels were similar in febrile episodes and controls (p > 0.05). In conclusion, sIL-2R, IL-6, and IL-8 levels may be helpful in the prediction of infection in febrile cancer patients with neutropenia and measurements of IL-1beta and TNF-alpha were not useful for identifying the presence and the type of infection in febrile neutropenic episodes in children.en_US
dc.identifier.citationSöker, M., Çolpan, L., Ece, A., Devecioğlu, C. ve Haspolat, Y. K. (2001). Serum levels of IL-1 beta, sIL-2R, IL-6, IL-8, and TNF-alpha in febrile children with cancer and neutropenia. Medical Oncology, 18(1), 51-57.en_US
dc.identifier.doi10.1385/MO:18:1:51
dc.identifier.endpage57en_US
dc.identifier.issn1357-0560
dc.identifier.issn1559-131X
dc.identifier.issue1en_US
dc.identifier.pmid11778970
dc.identifier.scopus2-s2.0-0034801639
dc.identifier.scopusqualityQ2
dc.identifier.startpage51en_US
dc.identifier.urihttps://hdl.handle.net/11468/8377
dc.identifier.volume18en_US
dc.identifier.wosWOS:000171343500006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSöker, Murat
dc.institutionauthorÇolpan, Leyla
dc.institutionauthorEce, Aydın
dc.institutionauthorDevecioğlu, Celal
dc.institutionauthorHaspolat, Yusuf Kenan
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMedical Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCytokineen_US
dc.subjectFebrile neutropeniaen_US
dc.subjectChildhooden_US
dc.subjectCanceren_US
dc.titleSerum levels of IL-1 beta, sIL-2R, IL-6, IL-8, and TNF-alpha in febrile children with cancer and neutropeniaen_US
dc.titleSerum levels of IL-1 beta, sIL-2R, IL-6, IL-8, and TNF-alpha in febrile children with cancer and neutropenia
dc.typeArticleen_US

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